PDCD1LG2

Programmed cell death 1 ligand 2
Identifiers
Symbols	PDCD1LG2; B7DC; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2; bA574F11.2
External IDs	OMIM: 605723 MGI: 1930125 HomoloGene: 10973 GeneCards: PDCD1LG2 Gene
Gene Ontology Molecular function • molecular_function • receptor activity Cellular component • extracellular region • plasma membrane • plasma membrane • endomembrane system • integral to membrane Biological process • immune response • T cell costimulation • positive regulation of T cell proliferation • negative regulation of T cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80380	58205
Ensembl	ENSG00000197646	ENSMUSG00000016498
UniProt	Q9BQ51	Q3U304
RefSeq (mRNA)	NM_025239	NM_021396.2
RefSeq (protein)	NP_079515	NP_067371.1
Location (UCSC)	Chr 9: 5.51 – 5.57 Mb	Chr 19: 29.49 – 29.55 Mb
PubMed search	[1]	[2]

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.^[1][2] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).

References

1. ^ Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ (Mar 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat Immunol 2 (3): 261–8. doi:10.1038/85330. PMID 11224527. 
2. ^ "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80380. 

Further reading

• Tseng SY, Otsuji M, Gorski K, et al. (2001). "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.". J. Exp. Med. 193 (7): 839–46. doi:10.1084/jem.193.7.839. PMC 2193370. PMID 11283156. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193370. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Brown JA, Dorfman DM, Ma FR, et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.". J. Immunol. 170 (3): 1257–66. PMID 12538684. 
• Youngnak P, Kozono Y, Kozono H, et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1.". Biochem. Biophys. Res. Commun. 307 (3): 672–7. doi:10.1016/S0006-291X(03)01257-9. PMID 12893276. 
• Tsushima F, Iwai H, Otsuki N, et al. (2003). "Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses.". Eur. J. Immunol. 33 (10): 2773–82. doi:10.1002/eji.200324084. PMID 14515261. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Aramaki O, Shirasugi N, Takayama T, et al. (2004). "Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.". Transplantation 77 (1): 6–12. doi:10.1097/01.TP.0000108637.65091.4B. PMID 14724428. 
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• He XH, Liu Y, Xu LH, Zeng YY (2004). "Cloning and identification of two novel splice variants of human PD-L2.". Acta Biochim. Biophys. Sin. (Shanghai) 36 (4): 284–9. doi:10.1093/abbs/36.4.284. PMID 15253154. 
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ohigashi Y, Sho M, Yamada Y, et al. (2005). "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.". Clin. Cancer Res. 11 (8): 2947–53. doi:10.1158/1078-0432.CCR-04-1469. PMID 15837746. 
• Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2006). "PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion.". Eur. J. Immunol. 35 (12): 3561–9. doi:10.1002/eji.200526347. PMID 16278812. 
• Pfistershammer K, Klauser C, Pickl WF, et al. (2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation.". Eur. J. Immunol. 36 (5): 1104–13. doi:10.1002/eji.200535344. PMC 2975063. PMID 16598819. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2975063. 
• Abelson AK, Johansson CM, Kozyrev SV, et al. (2007). "No evidence of association between genetic variants of the PDCD1 ligands and SLE.". Genes Immun. 8 (1): 69–74. doi:10.1038/sj.gene.6364360. PMID 17136123. 
• Mataki N, Kikuchi K, Kawai T, et al. (2007). "Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases.". Am. J. Gastroenterol. 102 (2): 302–12. doi:10.1111/j.1572-0241.2006.00948.x. PMID 17311651. 
• Wang SC, Lin CH, Ou TT, et al. (2007). "Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus.". J. Rheumatol. 34 (4): 721–5. doi:10.1093/rheumatology/34.8.721. PMID 17343323. 

External links

• MeSH PDCD1LG2+protein,+human