AKR1C4

Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4), also known as AKR1C4, is a human gene.cite web | title = Entrez Gene: AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1109| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.cite web | title = Entrez Gene: AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1109| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Binstock JM, Iyer RB, Hamby CV, "et al." |title=Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 2 |pages= 760–6 |year= 1992 |pmid= 1530633 |doi=
*cite journal | author=Winters CJ, Molowa DT, Guzelian PS |title=Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. |journal=Biochemistry |volume=29 |issue= 4 |pages= 1080–7 |year= 1990 |pmid= 2187532 |doi=
*cite journal | author=Khanna M, Qin KN, Cheng KC |title=Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1-6 |pages= 41–6 |year= 1995 |pmid= 7626489 |doi=
*cite journal | author=Khanna M, Qin KN, Wang RW, Cheng KC |title=Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases. |journal=J. Biol. Chem. |volume=270 |issue= 34 |pages= 20162–8 |year= 1995 |pmid= 7650035 |doi=
*cite journal | author=Khanna M, Qin KN, Klisak I, "et al." |title=Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization. |journal=Genomics |volume=25 |issue= 2 |pages= 588–90 |year= 1995 |pmid= 7789999 |doi=
*cite journal | author=Deyashiki Y, Ogasawara A, Nakayama T, "et al." |title=Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. |journal=Biochem. J. |volume=299 ( Pt 2) |issue= |pages= 545–52 |year= 1994 |pmid= 8172617 |doi=
*cite journal | author=Qin KN, New MI, Cheng KC |title=Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. |journal=J. Steroid Biochem. Mol. Biol. |volume=46 |issue= 6 |pages= 673–9 |year= 1994 |pmid= 8274401 |doi=
*cite journal | author=Kume T, Iwasa H, Shiraishi H, "et al." |title=Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver. |journal=Pharmacogenetics |volume=9 |issue= 6 |pages= 763–71 |year= 2000 |pmid= 10634139 |doi=
*cite journal | author=Nishizawa M, Nakajima T, Yasuda K, "et al." |title=Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. |journal=Genes Cells |volume=5 |issue= 2 |pages= 111–25 |year= 2000 |pmid= 10672042 |doi=
*cite journal | author=Dufort I, Labrie F, Luu-The V |title=Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 2 |pages= 841–6 |year= 2001 |pmid= 11158055 |doi=
*cite journal | author=Ozeki T, Takahashi Y, Kume T, "et al." |title=Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha. |journal=Biochem. J. |volume=355 |issue= Pt 2 |pages= 537–44 |year= 2001 |pmid= 11284743 |doi=
*cite journal | author=Ozeki T, Takahashi Y, Nakayama K, Kamataki T |title=Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. |journal=Arch. Biochem. Biophys. |volume=405 |issue= 2 |pages= 185–90 |year= 2002 |pmid= 12220531 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ozeki T, Takahashi Y, Nakayama K, "et al." |title=Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. |journal=Pharmacogenetics |volume=13 |issue= 1 |pages= 49–53 |year= 2003 |pmid= 12544512 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schüle C, Romeo E, Uzunov DP, "et al." |title=Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. |journal=Mol. Psychiatry |volume=11 |issue= 3 |pages= 261–72 |year= 2006 |pmid= 16344854 |doi= 10.1038/sj.mp.4001782

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