FMO5

Flavin containing monooxygenase 5, also known as FMO5, is a human gene.

PBB_Summary
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summary_text = Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.cite web | title = Entrez Gene: FMO5 flavin containing monooxygenase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2330| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hines RN, Cashman JR, Philpot RM, "et al." |title=The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. |journal=Toxicol. Appl. Pharmacol. |volume=125 |issue= 1 |pages= 1–6 |year= 1994 |pmid= 8128486 |doi= 10.1006/taap.1994.1042
*cite journal | author=Phillips IR, Dolphin CT, Clair P, "et al." |title=The molecular biology of the flavin-containing monooxygenases of man. |journal=Chem. Biol. Interact. |volume=96 |issue= 1 |pages= 17–32 |year= 1995 |pmid= 7720101 |doi=10.1016/0009-2797(94)03580-2
*cite journal | author=Overby LH, Buckpitt AR, Lawton MP, "et al." |title=Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. |journal=Arch. Biochem. Biophys. |volume=317 |issue= 1 |pages= 275–84 |year= 1995 |pmid= 7872795 |doi=10.1006/abbi.1995.1163
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Lawton MP, Cashman JR, Cresteil T, "et al." |title=A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. |journal=Arch. Biochem. Biophys. |volume=308 |issue= 1 |pages= 254–7 |year= 1994 |pmid= 8311461 |doi=10.1006/abbi.1994.1035
*cite journal | author=McCombie RR, Dolphin CT, Povey S, "et al." |title=Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. |journal=Genomics |volume=34 |issue= 3 |pages= 426–9 |year= 1996 |pmid= 8786146 |doi= 10.1006/geno.1996.0308
*cite journal | author=Gelb BD, Zhang J, Cotter PD, "et al." |title=Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. |journal=Genomics |volume=39 |issue= 3 |pages= 409–11 |year= 1997 |pmid= 9119381 |doi= 10.1006/geno.1996.4516
*cite journal | author=Overby LH, Carver GC, Philpot RM |title=Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. |journal=Chem. Biol. Interact. |volume=106 |issue= 1 |pages= 29–45 |year= 1997 |pmid= 9305407 |doi=10.1016/S0009-2797(97)00055-0
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Chung WG, Park CS, Roh HK, "et al." |title=Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. |journal=Jpn. J. Pharmacol. |volume=84 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11128045 |doi=10.1254/jjp.84.213
*cite journal | author=Janmohamed A, Dolphin CT, Phillips IR, Shephard EA |title=Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. |journal=Biochem. Pharmacol. |volume=62 |issue= 6 |pages= 777–86 |year= 2001 |pmid= 11551524 |doi=10.1016/S0006-2952(01)00718-3
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Krause RJ, Lash LH, Elfarra AA |title=Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity. |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 185–91 |year= 2003 |pmid= 12490590 |doi= 10.1124/jpet.102.042911
*cite journal | author=Furnes B, Feng J, Sommer SS, Schlenk D |title=Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. |journal=Drug Metab. Dispos. |volume=31 |issue= 2 |pages= 187–93 |year= 2003 |pmid= 12527699 |doi=10.1124/dmd.31.2.187
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zhang J, Cashman JR |title=Quantitative analysis of FMO gene mRNA levels in human tissues. |journal=Drug Metab. Dispos. |volume=34 |issue= 1 |pages= 19–26 |year= 2006 |pmid= 16183778 |doi= 10.1124/dmd.105.006171
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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