Rnd1

Rnd1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522–9 |issn=0962-8924 |doi=10.1016/j.tcb.2006.08.006] . It is encoded by the gene RND1.cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = ]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998). [supplied by OMIM] cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = ]

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References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nobes CD, Lauritzen I, Mattei MG, "et al." |title=A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. |journal=J. Cell Biol. |volume=141 |issue= 1 |pages= 187–97 |year= 1998 |pmid= 9531558 |doi=
*cite journal | author=Vayssière B, Zalcman G, Mahé Y, "et al." |title=Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. |journal=FEBS Lett. |volume=467 |issue= 1 |pages= 91–6 |year= 2000 |pmid= 10664463 |doi=
*cite journal | author=Aoki J, Katoh H, Mori K, Negishi M |title=Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 3 |pages= 604–8 |year= 2001 |pmid= 11095956 |doi= 10.1006/bbrc.2000.3842
*cite journal | author=Rohm B, Rahim B, Kleiber B, "et al." |title=The semaphorin 3A receptor may directly regulate the activity of small GTPases. |journal=FEBS Lett. |volume=486 |issue= 1 |pages= 68–72 |year= 2001 |pmid= 11108845 |doi=
*cite journal | author=Nancy V, Callebaut I, El Marjou A, de Gunzburg J |title=The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15076–84 |year= 2002 |pmid= 11786539 |doi= 10.1074/jbc.M109983200
*cite journal | author=Katoh H, Harada A, Mori K, Negishi M |title=Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2952–64 |year= 2002 |pmid= 11940653 |doi=
*cite journal | author=Hanzal-Bayer M, Renault L, Roversi P, "et al." |title=The complex of Arl2-GTP and PDE delta: from structure to function. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2095–106 |year= 2002 |pmid= 11980706 |doi= 10.1093/emboj/21.9.2095
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Oinuma I, Katoh H, Harada A, Negishi M |title=Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25671–7 |year= 2003 |pmid= 12730235 |doi= 10.1074/jbc.M303047200
*cite journal | author=Oinuma I, Ishikawa Y, Katoh H, Negishi M |title=The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. |journal=Science |volume=305 |issue= 5685 |pages= 862–5 |year= 2004 |pmid= 15297673 |doi= 10.1126/science.1097545
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Harada A, Katoh H, Negishi M |title=Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18418–24 |year= 2005 |pmid= 15738000 |doi= 10.1074/jbc.M411356200
*cite journal | author=Kim YS, Hori M, Yasuda K, Ozaki H |title=Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria. |journal=Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |volume=142 |issue= 4 |pages= 410–5 |year= 2006 |pmid= 16311049 |doi= 10.1016/j.cbpa.2005.08.028

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