MXD1

MAX dimerization protein 1, also known as MXD1, is a human gene.cite web | title = Entrez Gene: MXD1 MAX dimerization protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4084| accessdate = ]

PBB_Summary
section_title =
summary_text = MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.cite web | title = Entrez Gene: MXD1 MAX dimerization protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4084| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Grandori C, Cowley SM, James LP, Eisenman RN |title=The Myc/Max/Mad network and the transcriptional control of cell behavior. |journal=Annu. Rev. Cell Dev. Biol. |volume=16 |issue= |pages= 653–99 |year= 2001 |pmid= 11031250 |doi= 10.1146/annurev.cellbio.16.1.653
*cite journal | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1–14 |year= 2001 |pmid= 11602341 |doi=
*cite journal | author=Shapiro DN, Valentine V, Eagle L, "et al." |title=Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25. |journal=Genomics |volume=23 |issue= 1 |pages= 282–5 |year= 1995 |pmid= 7829091 |doi= 10.1006/geno.1994.1496
*cite journal | author=Ayer DE, Lawrence QA, Eisenman RN |title=Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. |journal=Cell |volume=80 |issue= 5 |pages= 767–76 |year= 1995 |pmid= 7889570 |doi=
*cite journal | author=Edelhoff S, Ayer DE, Zervos AS, "et al." |title=Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. |journal=Oncogene |volume=9 |issue= 2 |pages= 665–8 |year= 1994 |pmid= 8290278 |doi=
*cite journal | author=Ayer DE, Kretzner L, Eisenman RN |title=Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. |journal=Cell |volume=72 |issue= 2 |pages= 211–22 |year= 1993 |pmid= 8425218 |doi=
*cite journal | author=Hassig CA, Fleischer TC, Billin AN, "et al." |title=Histone deacetylase activity is required for full transcriptional repression by mSin3A. |journal=Cell |volume=89 |issue= 3 |pages= 341–7 |year= 1997 |pmid= 9150133 |doi=
*cite journal | author=Laherty CD, Yang WM, Sun JM, "et al." |title=Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. |journal=Cell |volume=89 |issue= 3 |pages= 349–56 |year= 1997 |pmid= 9150134 |doi=
*cite journal | author=Gupta K, Anand G, Yin X, "et al." |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. |journal=Oncogene |volume=16 |issue= 9 |pages= 1149–59 |year= 1998 |pmid= 9528857 |doi= 10.1038/sj.onc.1201634
*cite journal | author=FitzGerald MJ, Arsura M, Bellas RE, "et al." |title=Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. |journal=Oncogene |volume=18 |issue= 15 |pages= 2489–98 |year= 1999 |pmid= 10229200 |doi= 10.1038/sj.onc.1202611
*cite journal | author=Khan MM, Nomura T, Kim H, "et al." |title=Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. |journal=Mol. Cell |volume=7 |issue= 6 |pages= 1233–43 |year= 2001 |pmid= 11430826 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nikiforov MA, Popov N, Kotenko I, "et al." |title=The Mad and Myc basic domains are functionally equivalent. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11094–9 |year= 2003 |pmid= 12538578 |doi= 10.1074/jbc.M212298200
*cite journal | author=Nair SK, Burley SK |title=X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. |journal=Cell |volume=112 |issue= 2 |pages= 193–205 |year= 2003 |pmid= 12553908 |doi=
*cite journal | author=Siegel PM, Shu W, Massagué J |title=Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35444–50 |year= 2003 |pmid= 12824180 |doi= 10.1074/jbc.M301413200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Zada AA, Pulikkan JA, Bararia D, "et al." |title=Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. |journal=Leukemia |volume=20 |issue= 12 |pages= 2137–46 |year= 2007 |pmid= 17082780 |doi= 10.1038/sj.leu.2404438

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