UBE2A

Ubiquitin-conjugating enzyme E2A (RAD6 homolog), also known as UBE2A, is a human gene.cite web | title = Entrez Gene: UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7319| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.cite web | title = Entrez Gene: UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7319| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Koken MH, Smit EM, Jaspers-Dekker I, "et al." |title=Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. |journal=Genomics |volume=12 |issue= 3 |pages= 447–53 |year= 1992 |pmid= 1559696 |doi=
*cite journal | author=Koken MH, Reynolds P, Jaspers-Dekker I, "et al." |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865–9 |year= 1991 |pmid= 1717990 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Tateishi S, Sakuraba Y, Masuyama S, "et al." |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927–32 |year= 2000 |pmid= 10884424 |doi=
*cite journal | author=Xin H, Lin W, Sumanasekera W, "et al." |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847–54 |year= 2000 |pmid= 10908344 |doi=
*cite journal | author=Miura T, Klaus W, Ross A, "et al." |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89–92 |year= 2003 |pmid= 11885984 |doi=
*cite journal | author=Shekhar MP, Lyakhovich A, Visscher DW, "et al." |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115–24 |year= 2002 |pmid= 11929833 |doi=
*cite journal | author=Sarcevic B, Mawson A, Baker RT, Sutherland RL |title=Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation. |journal=EMBO J. |volume=21 |issue= 8 |pages= 2009–18 |year= 2002 |pmid= 11953320 |doi= 10.1093/emboj/21.8.2009
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Suzumori N, Burns KH, Yan W, Matzuk MM |title=RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 550–5 |year= 2003 |pmid= 12525704 |doi= 10.1073/pnas.0234474100
*cite journal | author=Lyakhovich A, Shekhar MP |title=Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response. |journal=Mol. Cell. Biol. |volume=23 |issue= 7 |pages= 2463–75 |year= 2003 |pmid= 12640129 |doi=
*cite journal | author=Kunapuli P, Somerville R, Still IH, Cowell JK |title=ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins. |journal=Oncogene |volume=22 |issue= 22 |pages= 3417–23 |year= 2003 |pmid= 12776193 |doi= 10.1038/sj.onc.1206408
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Nascimento RM, Otto PA, de Brouwer AP, Vianna-Morgante AM |title=UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. |journal=Am. J. Hum. Genet. |volume=79 |issue= 3 |pages= 549–55 |year= 2006 |pmid= 16909393 |doi= 10.1086/507047

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