SEPT7

Septin 7, also known as SEPT7, is a human gene.cite web | title = Entrez Gene: SEPT7 septin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=989| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: SEPT7 septin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=989| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakatsuru S, Sudo K, Nakamura Y |title=Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 1 |pages= 82–7 |year= 1994 |pmid= 8037772 |doi= 10.1006/bbrc.1994.1896
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hsu SC, Hazuka CD, Roth R, "et al." |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111–22 |year= 1998 |pmid= 9655500 |doi=
*cite journal | author=Oegema K, Savoian MS, Mitchison TJ, Field CM |title=Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. |journal=J. Cell Biol. |volume=150 |issue= 3 |pages= 539–52 |year= 2000 |pmid= 10931866 |doi=
*cite journal | author=Joberty G, Perlungher RR, Sheffield PJ, "et al." |title=Borg proteins control septin organization and are negatively regulated by Cdc42. |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= 861–6 |year= 2001 |pmid= 11584266 |doi= 10.1038/ncb1001-861
*cite journal | author=Surka MC, Tsang CW, Trimble WS |title=The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3532–45 |year= 2003 |pmid= 12388755 |doi= 10.1091/mbc.E02-01-0042
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Koshelev YA, Kiselev SL, Georgiev GP |title=Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro. |journal=Dokl. Biochem. Biophys. |volume=391 |issue= |pages= 195–7 |year= 2004 |pmid= 14531065 |doi=
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Nagata K, Asano T, Nozawa Y, Inagaki M |title=Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55895–904 |year= 2005 |pmid= 15485874 |doi= 10.1074/jbc.M406153200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Low C, Macara IG |title=Structural analysis of septin 2, 6, and 7 complexes. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30697–706 |year= 2006 |pmid= 16914550 |doi= 10.1074/jbc.M605179200
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Sirajuddin M, Farkasovsky M, Hauer F, "et al." |title=Structural insight into filament formation by mammalian septins. |journal=Nature |volume=449 |issue= 7160 |pages= 311–5 |year= 2007 |pmid= 17637674 |doi= 10.1038/nature06052
*cite journal | author=Kremer BE, Adang LA, Macara IG |title=Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. |journal=Cell |volume=130 |issue= 5 |pages= 837–50 |year= 2007 |pmid= 17803907 |doi= 10.1016/j.cell.2007.06.053

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