FOLR2

Folate receptor 2 (fetal), also known as FOLR2, is a human gene.cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Henderson GB |title=Folate-binding proteins. |journal=Annu. Rev. Nutr. |volume=10 |issue= |pages= 319–35 |year= 1990 |pmid= 2166548 |doi= 10.1146/annurev.nu.10.070190.001535
*cite journal | author=Kawasaki K, Fearnhead RW |title=On the relationship between tetracycline and the incremental lines in dentine. |journal=J. Anat. |volume=119 |issue= Pt 1 |pages= 49–59 |year= 1975 |pmid= 1133088 |doi=
*cite journal | author=Ragoussis J, Senger G, Trowsdale J, Campbell IG |title=Genomic organization of the human folate receptor genes on chromosome 11q13. |journal=Genomics |volume=14 |issue= 2 |pages= 423–30 |year= 1992 |pmid= 1330883 |doi=
*cite journal | author=Freisheim JH, Price EM, Ratnam M |title=Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. |journal=Adv. Enzyme Regul. |volume=29 |issue= |pages= 13–26 |year= 1990 |pmid= 2561247 |doi=
*cite journal | author=Ratnam M, Marquardt H, Duhring JL, Freisheim JH |title=Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8249–54 |year= 1990 |pmid= 2605182 |doi=
*cite journal | author=Yan W, Ratnam M |title=Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. |journal=Biochemistry |volume=34 |issue= 44 |pages= 14594–600 |year= 1995 |pmid= 7578066 |doi=
*cite journal | author=van Heyningen V, Little PF |title=Report of the fourth international workshop on human chromosome 11 mapping 1994. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 127–58 |year= 1995 |pmid= 7698003 |doi=
*cite journal | author=Sadasivan E, Cedeno MM, Rothenberg SP |title=Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 4725–35 |year= 1994 |pmid= 8106441 |doi=
*cite journal | author=Shen F, Ross JF, Wang X, Ratnam M |title=Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. |journal=Biochemistry |volume=33 |issue= 5 |pages= 1209–15 |year= 1994 |pmid= 8110752 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Page ST, Owen WC, Price K, Elwood PC |title=Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. |journal=J. Mol. Biol. |volume=229 |issue= 4 |pages= 1175–83 |year= 1993 |pmid= 8445646 |doi= 10.1006/jmbi.1993.1116
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Wang J, Shen F, Yan W, "et al." |title=Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. |journal=Biochemistry |volume=36 |issue= 47 |pages= 14583–92 |year= 1998 |pmid= 9398177 |doi= 10.1021/bi970845w
*cite journal | author=Nakashima-Matsushita N, Homma T, Yu S, "et al." |title=Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. |journal=Arthritis Rheum. |volume=42 |issue= 8 |pages= 1609–16 |year= 1999 |pmid= 10446858 |doi= 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L |doilabel=10.1002/1529-0131(199908)42:81609::AID-ANR73.0.CO;2-L
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hao H, Qi H, Ratnam M |title=Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. |journal=Blood |volume=101 |issue= 11 |pages= 4551–60 |year= 2003 |pmid= 12543860 |doi= 10.1182/blood-2002-10-3174

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