IL17RA

IL17RA

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.cite web | title = Entrez Gene: IL17RA interleukin 17 receptor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23765| accessdate = ]

PBB_Summary
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summary_text = Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.cite web | title = Entrez Gene: IL17RA interleukin 17 receptor A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23765| accessdate = ]

ee also

* Interleukin-17 receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yao Z, Spriggs MK, Derry JM, "et al." |title=Molecular characterization of the human interleukin (IL)-17 receptor. |journal=Cytokine |volume=9 |issue= 11 |pages= 794–800 |year= 1998 |pmid= 9367539 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Honorati MC, Meliconi R, Pulsatelli L, "et al." |title=High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. |journal=Rheumatology (Oxford) |volume=40 |issue= 5 |pages= 522–7 |year= 2001 |pmid= 11371660 |doi=
*cite journal | author=Footz TK, Brinkman-Mills P, Banting GS, "et al." |title=Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. |journal=Genome Res. |volume=11 |issue= 6 |pages= 1053–70 |year= 2001 |pmid= 11381032 |doi= 10.1101/gr.154901
*cite journal | author=Haudenschild D, Moseley T, Rose L, Reddi AH |title=Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4309–16 |year= 2002 |pmid= 11706037 |doi= 10.1074/jbc.M109372200
*cite journal | author=Kehlen A, Thiele K, Riemann D, Langner J |title=Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. |journal=Clin. Exp. Immunol. |volume=127 |issue= 3 |pages= 539–46 |year= 2002 |pmid= 11966773 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Steiner GE, Newman ME, Paikl D, "et al." |title=Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. |journal=Prostate |volume=56 |issue= 3 |pages= 171–82 |year= 2003 |pmid= 12772186 |doi= 10.1002/pros.10238
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=McAllister F, Henry A, Kreindler JL, "et al." |title=Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. |journal=J. Immunol. |volume=175 |issue= 1 |pages= 404–12 |year= 2005 |pmid= 15972674 |doi=
*cite journal | author=Pongcharoen S, Niumsup P, Sanguansermsri D, "et al." |title=The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells. |journal=Am. J. Reprod. Immunol. |volume=55 |issue= 4 |pages= 291–300 |year= 2006 |pmid= 16533341 |doi= 10.1111/j.1600-0897.2006.00366.x
*cite journal | author=Toy D, Kugler D, Wolfson M, "et al." |title=Cutting edge: interleukin 17 signals through a heteromeric receptor complex. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 36–9 |year= 2006 |pmid= 16785495 |doi=
*cite journal | author=Wang X, Dong Z, Zhu DD, Guan B |title=Expression profile of immune-associated genes in nasal polyps. |journal=Ann. Otol. Rhinol. Laryngol. |volume=115 |issue= 6 |pages= 450–6 |year= 2006 |pmid= 16805377 |doi=
*cite journal | author=Rong Z, Cheng L, Ren Y, "et al." |title=Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. |journal=Cell. Signal. |volume=19 |issue= 7 |pages= 1514–20 |year= 2007 |pmid= 17346928 |doi= 10.1016/j.cellsig.2007.01.025
*cite journal | author=Maitra A, Shen F, Hanel W, "et al." |title=Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 18 |pages= 7506–11 |year= 2007 |pmid= 17456598 |doi= 10.1073/pnas.0611589104

External links

*

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