Homeobox D11, also known as HOXD11, is a human gene.cite web | title = Entrez Gene: HOXD11 homeobox D11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3237| accessdate = ]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.cite web | title = Entrez Gene: HOXD11 homeobox D11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3237| accessdate = ] cite journal | author = Davis AP, Capecchi MR | title = Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11 | journal = Development | volume = 120 | issue = 8 | pages = 2187–98 | year = 1994 | month = August | pmid = 7925020 | url = http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=7925020 | issn = ] cite journal | author = Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR | title = Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11 | journal = Nature | volume = 375 | issue = 6534 | pages = 791–5 | year = 1995 | month = June | pmid = 7596412 | doi = 10.1038/375791a0 | url = ] cite journal | author = Davis AP, Capecchi MR | title = A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse | journal = Development | volume = 122 | issue = 4 | pages = 1175–85 | year = 1996 | month = April | pmid = 8620844 | url = http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=8620844 | issn = ]

ee also

* Homeobox


Further reading

citations =
*cite journal | author=Johnson RL, Tabin CJ |title=Molecular models for vertebrate limb development |journal=Cell |volume=90 |issue= 6 |pages= 979–90 |year= 1997 |pmid= 9323126 |doi=
*cite journal | author=Goodman FR |title=Limb malformations and the human HOX genes |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256–65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, "et al." |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448–58 |year= 1997 |pmid= 9343407 |doi=
*cite journal | author=Hérault Y, Beckers J, Gérard M, Duboule D |title=Hox gene expression in limbs: colinearity by opposite regulatory controls |journal=Dev. Biol. |volume=208 |issue= 1 |pages= 157–65 |year= 1999 |pmid= 10075849 |doi= 10.1006/dbio.1998.9179
*cite journal | author=Del Campo M, Jones MC, Veraksa AN, "et al." |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=
*cite journal | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1 |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=
*cite journal | author=Patterson LT, Pembaur M, Potter SS |title=Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney |journal=Development |volume=128 |issue= 11 |pages= 2153–61 |year= 2001 |pmid= 11493536 |doi=
*cite journal | author=Goodman FR, Majewski F, Collins AL, Scambler PJ |title=A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly |journal=Am. J. Hum. Genet. |volume=70 |issue= 2 |pages= 547–55 |year= 2002 |pmid= 11778160 |doi=
*cite journal | author=Taketani T, Taki T, Shibuya N, "et al." |title=The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15) |journal=Cancer Res. |volume=62 |issue= 1 |pages= 33–7 |year= 2002 |pmid= 11782354 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Boulet AM, Capecchi MR |title=Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse |journal=Dev. Biol. |volume=249 |issue= 1 |pages= 96–107 |year= 2002 |pmid= 12217321 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhao X, Sun M, Zhao J, "et al." |title=Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 361–71 |year= 2007 |pmid= 17236141 |doi= 10.1086/511387

External links


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