BTLA

B and T lymphocyte attenuator, also known as BTLA, is a human gene.cite web | title = Entrez Gene: BTLA B and T lymphocyte associated| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151888| accessdate = ] BTLA has also been designated as CD272 (cluster of differentiation 272).

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summary_text = BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 (MIM 600244) and CTLA4 (MIM 123890), BTLA interacts with a B7 homolog, B7H4. [supplied by OMIM] cite web | title = Entrez Gene: BTLA B and T lymphocyte associated| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151888| accessdate = ] However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family (TNF) receptors, not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (ligand) superfamily, member 14 (TNFSF14), also known as herpes virus etry mdiator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pao LI, Bedzyk WD, Persin C, Cambier JC |title=Molecular targets of CD45 in B cell antigen receptor signal transduction. |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1116–24 |year= 1997 |pmid= 9013950 |doi=
*cite journal | author=Pao LI, Cambier JC |title=Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2663–9 |year= 1997 |pmid= 9058799 |doi=
*cite journal | author=Vilen BJ, Famiglietti SJ, Carbone AM, "et al." |title=B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. |journal=J. Immunol. |volume=159 |issue= 1 |pages= 231–43 |year= 1997 |pmid= 9200459 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Watanabe N, Gavrieli M, Sedy JR, "et al." |title=BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. |journal=Nat. Immunol. |volume=4 |issue= 7 |pages= 670–9 |year= 2003 |pmid= 12796776 |doi= 10.1038/ni944
*cite journal | author=Gavrieli M, Watanabe N, Loftin SK, "et al." |title=Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1236–43 |year= 2004 |pmid= 14652006 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Sedy JR, Gavrieli M, Potter KG, "et al." |title=B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. |journal=Nat. Immunol. |volume=6 |issue= 1 |pages= 90–8 |year= 2005 |pmid= 15568026 |doi= 10.1038/ni1144
*cite journal | author=Gonzalez LC, Loyet KM, Calemine-Fenaux J, "et al." |title=A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 4 |pages= 1116–21 |year= 2005 |pmid= 15647361 |doi= 10.1073/pnas.0409071102
*cite journal | author=Cheung TC, Humphreys IR, Potter KG, "et al." |title=Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13218–23 |year= 2005 |pmid= 16131544 |doi= 10.1073/pnas.0506172102
*cite journal | author=Compaan DM, Gonzalez LC, Tom I, "et al." |title=Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39553–61 |year= 2006 |pmid= 16169851 |doi= 10.1074/jbc.M507629200
*cite journal | author=Otsuki N, Kamimura Y, Hashiguchi M, Azuma M |title=Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 4 |pages= 1121–7 |year= 2006 |pmid= 16643847 |doi= 10.1016/j.bbrc.2006.03.242
*cite journal | author=Wang XF, Chen YJ, Wang Q, "et al." |title=Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells. |journal=Tissue Antigens |volume=69 |issue= 2 |pages= 145–53 |year= 2007 |pmid= 17257317 |doi= 10.1111/j.1399-0039.2006.00710.x

External links

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