FOS-like antigen 2, also known as FOSL2, is a human gene.cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url =| accessdate = ]

section_title =
summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url =| accessdate = ]

ee also

* AP-1 (transcription factor)


Further reading

citations =
*cite journal | author=Matsui M, Tokuhara M, Konuma Y, "et al." |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249–55 |year= 1990 |pmid= 2107490 |doi=
*cite journal | author=Molven A, Houge G, Berger R |title=Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. |journal=Genomics |volume=38 |issue= 1 |pages= 72–5 |year= 1997 |pmid= 8954781 |doi= 10.1006/geno.1996.0593
*cite journal | author=Outinen PA, Sood SK, Pfeifer SI, "et al." |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=
*cite journal | author=Miyamoto NG, Medberry PS, Hesselgesser J, "et al." |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78–90 |year= 2000 |pmid= 10713367 |doi=
*cite journal | author=Ng DC, Shafaee S, Lee D, Bikle DD |title=Requirement of an AP-1 site in the calcium response region of the involucrin promoter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24080–8 |year= 2000 |pmid= 10816578 |doi= 10.1074/jbc.M002508200
*cite journal | author=Bamberger AM, Milde-Langosch K, Rössing E, "et al." |title=Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 9 |pages= 545–50 |year= 2001 |pmid= 11570575 |doi=
*cite journal | author=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25–33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929
*cite journal | author=Benkoussa M, Brand C, Delmotte MH, "et al." |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4522–34 |year= 2002 |pmid= 12052862 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Santalucía T, Christmann M, Yacoub MH, Brand NJ |title=Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. |journal=Cardiovasc. Res. |volume=59 |issue= 3 |pages= 639–48 |year= 2004 |pmid= 14499865 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

External links


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