GABRA6


GABRA6

Gamma-aminobutyric acid (GABA) A receptor, alpha 6, also known as GABRA6, is a human gene.cite web | title = Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2559| accessdate = ]

PBB_Summary
section_title =
summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.cite web | title = Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2559| accessdate = ]

One study has found a genetic variant in the gene to be associated with the personality trait neuroticism. [Cite journal
author = Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder & Margit Burmeister
title = Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism
journal = Biological Psychiatry
volume = 55
issue = 3
pages = 244–249
year = 2004
month = February
pmid = 14744464
]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hicks AA, Bailey ME, Riley BP, "et al." |title=Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis. |journal=Genomics |volume=20 |issue= 2 |pages= 285–8 |year= 1994 |pmid= 8020978 |doi= 10.1006/geno.1994.1167
*cite journal | author=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=
*cite journal | author=Hadingham KL, Garrett EM, Wafford KA, "et al." |title=Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. |journal=Mol. Pharmacol. |volume=49 |issue= 2 |pages= 253–9 |year= 1996 |pmid= 8632757 |doi=
*cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome. |journal=Gene |volume=227 |issue= 2 |pages= 213–22 |year= 1999 |pmid= 10023064 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sen S, Villafuerte S, Nesse R, "et al." |title=Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. |journal=Biol. Psychiatry |volume=55 |issue= 3 |pages= 244–9 |year= 2004 |pmid= 14744464 |doi=
*cite journal | author=Peran M, Hooper H, Rayner SL, "et al." |title=GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells. |journal=Neurosci. Lett. |volume=364 |issue= 2 |pages= 67–70 |year= 2004 |pmid= 15196679 |doi= 10.1016/j.neulet.2004.03.081
*cite journal | author=Uhart M, McCaul ME, Oswald LM, "et al." |title=GABRA6 gene polymorphism and an attenuated stress response. |journal=Mol. Psychiatry |volume=9 |issue= 11 |pages= 998–1006 |year= 2005 |pmid= 15197399 |doi= 10.1038/sj.mp.4001535
*cite journal | author=Wang W, Stock RE, Gronostajski RM, "et al." |title=A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53491–7 |year= 2005 |pmid= 15466411 |doi= 10.1074/jbc.M410370200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Lucht M, Barnow S, Schroeder W, "et al." |title=Negative perceived paternal parenting is associated with dopamine D2 receptor exon 8 and GABA(A) alpha 6 receptor variants: an explorative study. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 2 |pages= 167–72 |year= 2006 |pmid= 16402352 |doi= 10.1002/ajmg.b.30255
*cite journal | author=Park CS, Park SY, Lee CS, "et al." |title=Association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population. |journal=J. Korean Med. Sci. |volume=21 |issue= 3 |pages= 533–8 |year= 2007 |pmid= 16778401 |doi=
*cite journal | author=Kobayashi Y, Akiyoshi J, Kanehisa M, "et al." |title=Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 1 |pages= 9 |year= 2007 |pmid= 17167337 |doi= 10.1097/YPG.0b013e32801118bc
*cite journal | author=Lee YC, Wang HP, Chiu HM, "et al." |title=GABRA6 genetic polymorphism is associated with the risk of functional heartburn in Chinese. |journal=J. Gastroenterol. Hepatol. |volume=22 |issue= 2 |pages= 227–33 |year= 2007 |pmid= 17295876 |doi= 10.1111/j.1440-1746.2006.04441.x

External links

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