LGMN


LGMN

Legumain, also known as LGMN, is a human gene.cite web | title = Entrez Gene: LGMN legumain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5641| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.cite web | title = Entrez Gene: LGMN legumain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5641| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Tanaka T, Inazawa J, Nakamura Y |title=Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 1-2 |pages= 120–3 |year= 1996 |pmid= 8893817 |doi=
*cite journal | author=Chen JM, Dando PM, Rawlings ND, "et al." |title=Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 8090–8 |year= 1997 |pmid= 9065484 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Chen JM, Dando PM, Stevens RA, "et al." |title=Cloning and expression of mouse legumain, a lysosomal endopeptidase. |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 111–7 |year= 1998 |pmid= 9742219 |doi=
*cite journal | author=Halfon S, Patel S, Vega F, "et al." |title=Autocatalytic activation of human legumain at aspartic acid residues. |journal=FEBS Lett. |volume=438 |issue= 1-2 |pages= 114–8 |year= 1998 |pmid= 9821970 |doi=
*cite journal | author=Manoury B, Hewitt EW, Morrice N, "et al." |title=An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. |journal=Nature |volume=396 |issue= 6712 |pages= 695–9 |year= 1999 |pmid= 9872320 |doi= 10.1038/25379
*cite journal | author=Chen JM, Rawlings ND, Stevens RA, Barrett AJ |title=Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. |journal=FEBS Lett. |volume=441 |issue= 3 |pages= 361–5 |year= 1999 |pmid= 9891971 |doi=
*cite journal | author=Chen JM, Fortunato M, Barrett AJ |title=Activation of human prolegumain by cleavage at a C-terminal asparagine residue. |journal=Biochem. J. |volume=352 Pt 2 |issue= |pages= 327–34 |year= 2001 |pmid= 11085925 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li DN, Matthews SP, Antoniou AN, "et al." |title=Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38980–90 |year= 2003 |pmid= 12860980 |doi= 10.1074/jbc.M305930200
*cite journal | author=Burster T, Beck A, Tolosa E, "et al." |title=Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. |journal=J. Immunol. |volume=172 |issue= 9 |pages= 5495–503 |year= 2004 |pmid= 15100291 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Murthy RV, Arbman G, Gao J, "et al." |title=Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2293–9 |year= 2005 |pmid= 15788679 |doi= 10.1158/1078-0432.CCR-04-1642
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2

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