Kruppel-like factor 12, also known as KLF12, is a human gene.cite web | title = Entrez Gene: KLF12 Kruppel-like factor 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11278| accessdate = ]

section_title =
summary_text = Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: KLF12 Kruppel-like factor 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11278| accessdate = ]

ee also

* Kruppel-like factors


Further reading

citations =
*cite journal | author=Imhof A, Schuierer M, Werner O, "et al." |title=Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 194–204 |year= 1999 |pmid= 9858544 |doi=
*cite journal | author=Roth C, Schuierer M, Günther K, Buettner R |title=Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). |journal=Genomics |volume=63 |issue= 3 |pages= 384–90 |year= 2000 |pmid= 10704285 |doi= 10.1006/geno.1999.6084
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Schuierer M, Hilger-Eversheim K, Dobner T, "et al." |title=Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27944–9 |year= 2001 |pmid= 11373277 |doi= 10.1074/jbc.M100070200
*cite journal | author=Zhu CH, Huang Y, Broman MT, Domann FE |title=Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter. |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1-2 |pages= 85–91 |year= 2001 |pmid= 11406275 |doi=
*cite journal | author=Chen C, Brabham WW, Stultz BG, "et al." |title=Defining a common region of deletion at 13q21 in human cancers. |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 333–44 |year= 2001 |pmid= 11433524 |doi= 10.1002/gcc.1152
*cite journal | author=Rozenblum E, Vahteristo P, Sandberg T, "et al." |title=A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 111–21 |year= 2002 |pmid= 11935316 |doi= 10.1007/s00439-001-0646-6
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Suda S, Rai T, Sohara E, "et al." |title=Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 1 |pages= 246–52 |year= 2006 |pmid= 16615998 |doi= 10.1016/j.bbrc.2006.03.138

External links


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  • Kruppel-like factors — The Krüppel like family of transcription factors (Klfs), so named for their homology to the Drosophila melanogaster Krüppel protein, have been extensively studied for their roles in cell proliferation, differentiation and survival, especially in… …   Wikipedia

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