GRLF1

Glucocorticoid receptor DNA binding factor 1, also known as GRLF1, is a human gene.cite web | title = Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2909| accessdate = ]

PBB_Summary
section_title =
summary_text = The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.cite web | title = Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2909| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=LeClerc S, Palaniswami R, Xie BX, Govindan MV |title=Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression. |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17333–40 |year= 1991 |pmid= 1894621 |doi=
*cite journal | author=Warriar N, Pagé N, Govindan MV |title=Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18662–71 |year= 1996 |pmid= 8702520 |doi=
*cite journal | author=Tikoo A, Czekay S, Viars C, "et al." |title=p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. |journal=Gene |volume=257 |issue= 1 |pages= 23–31 |year= 2001 |pmid= 11054565 |doi=
*cite journal | author=Nagase T, Kikuno R, Hattori A, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Barberis D, Casazza A, Sordella R, "et al." |title=p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling. |journal=J. Cell. Sci. |volume=118 |issue= Pt 20 |pages= 4689–700 |year= 2006 |pmid= 16188938 |doi= 10.1242/jcs.02590
*cite journal | author=Holinstat M, Knezevic N, Broman M, "et al." |title=Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoG
journal=J. Biol. Chem. |volume=281 |issue= 4 |pages= 2296–305 |year= 2006 |pmid= 16308318 |doi= 10.1074/jbc.M511248200
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Mammoto T, Parikh SM, Mammoto A, "et al." |title=Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. |journal=J. Biol. Chem. |volume=282 |issue= 33 |pages= 23910–8 |year= 2007 |pmid= 17562701 |doi= 10.1074/jbc.M702169200

External links

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