KLK12

KLK12

Kallikrein-related peptidase 12, also known as KLK12, is a human gene.cite web | title = Entrez Gene: KLK12 kallikrein-related peptidase 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849| accessdate = ]

PBB_Summary
section_title =
summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.cite web | title = Entrez Gene: KLK12 kallikrein-related peptidase 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=43849| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Diamandis EP, Yousef GM, Luo LY, "et al." |title=The new human kallikrein gene family: implications in carcinogenesis. |journal=Trends Endocrinol. Metab. |volume=11 |issue= 2 |pages= 54–60 |year= 2001 |pmid= 10675891 |doi=
*cite journal | author=Yousef GM, Luo LY, Diamandis EP |title=Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. |journal=Anticancer Res. |volume=19 |issue= 4B |pages= 2843–52 |year= 2000 |pmid= 10652563 |doi=
*cite journal | author=Harvey TJ, Hooper JD, Myers SA, "et al." |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397–406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200
*cite journal | author=Yousef GM, Chang A, Scorilas A, Diamandis EP |title=Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 125–33 |year= 2000 |pmid= 11006094 |doi= 10.1006/bbrc.2000.3448
*cite journal | author=Gan L, Lee I, Smith R, "et al." |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=
*cite journal | author=Yousef GM, Magklara A, Diamandis EP |title=KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. |journal=Genomics |volume=69 |issue= 3 |pages= 331–41 |year= 2001 |pmid= 11056051 |doi= 10.1006/geno.2000.6346
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Shinmura K, Tao H, Yamada H, "et al." |title=Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity. |journal=Hum. Mutat. |volume=24 |issue= 3 |pages= 273–4 |year= 2005 |pmid= 15300858 |doi= 10.1002/humu.9270
*cite journal | author= |title=Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 635–824 |year= 2006 |pmid= 16800723 |doi= 10.1515/BC.2006.081
*cite journal | author=Lundwall A, Band V, Blaber M, "et al." |title=A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 637–41 |year= 2006 |pmid= 16800724 |doi= 10.1515/BC.2006.082
*cite journal | author=Memari N, Jiang W, Diamandis EP, Luo LY |title=Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). |journal=Biol. Chem. |volume=388 |issue= 4 |pages= 427–35 |year= 2007 |pmid= 17391064 |doi= 10.1515/BC.2007.049

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