HCN1

HCN1

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1, also known as HCN1, is a human gene.cite web | title = Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980| accessdate = ]

PBB_Summary
section_title =
summary_text = Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. [supplied by OMIM] cite web | title = Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980| accessdate = ]

ee also

* Cyclic nucleotide-gated ion channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hofmann F, Biel M, Kaupp UB |title=International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 455–62 |year= 2006 |pmid= 16382102 |doi= 10.1124/pr.57.4.8
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Santoro B, Grant SG, Bartsch D, Kandel ER |title=Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14815–20 |year= 1998 |pmid= 9405696 |doi=
*cite journal | author=Santoro B, Liu DT, Yao H, "et al." |title=Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. |journal=Cell |volume=93 |issue= 5 |pages= 717–29 |year= 1998 |pmid= 9630217 |doi=
*cite journal | author=Ludwig A, Zong X, Jeglitsch M, "et al." |title=A family of hyperpolarization-activated mammalian cation channels. |journal=Nature |volume=393 |issue= 6685 |pages= 587–91 |year= 1998 |pmid= 9634236 |doi= 10.1038/31255
*cite journal | author=Kleiderlein JJ, Nisson PE, Jessee J, "et al." |title=CCG repeats in cDNAs from human brain. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 666–73 |year= 1999 |pmid= 9921901 |doi=
*cite journal | author=Ulens C, Tytgat J |title=Functional heteromerization of HCN1 and HCN2 pacemaker channels. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6069–72 |year= 2001 |pmid= 11133998 |doi= 10.1074/jbc.C000738200
*cite journal | author=Proenza C, Tran N, Angoli D, "et al." |title=Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29634–42 |year= 2002 |pmid= 12034718 |doi= 10.1074/jbc.M200504200
*cite journal | author=Chaplan SR, Guo HQ, Lee DH, "et al." |title=Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1169–78 |year= 2003 |pmid= 12598605 |doi=
*cite journal | author=Lesso H, Li RA |title=Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22290–7 |year= 2003 |pmid= 12668666 |doi= 10.1074/jbc.M302466200
*cite journal | author=Bender RA, Soleymani SV, Brewster AL, "et al." |title=Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. |journal=J. Neurosci. |volume=23 |issue= 17 |pages= 6826–36 |year= 2003 |pmid= 12890777 |doi=
*cite journal | author=Much B, Wahl-Schott C, Zong X, "et al." |title=Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43781–6 |year= 2003 |pmid= 12928435 |doi= 10.1074/jbc.M306958200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

External links

*

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