UBE2H

Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), also known as UBE2H, is a human gene.cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wefes I, Mastrandrea LD, Haldeman M, "et al." |title=Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 11 |pages= 4982–6 |year= 1995 |pmid= 7761435 |doi=
*cite journal | author=Kaiser P, Seufert W, Höfferer L, "et al." |title=A human ubiquitin-conjugating enzyme homologous to yeast UBC8. |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 8797–802 |year= 1994 |pmid= 8132613 |doi=
*cite journal | author=Kaiser P, Mandl S, Schweiger M, Schneider R |title=Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2. |journal=FEBS Lett. |volume=377 |issue= 2 |pages= 193–6 |year= 1996 |pmid= 8543049 |doi=
*cite journal | author=Hayashida S, Yamasaki K, Asada Y, "et al." |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. |journal=Genomics |volume=66 |issue= 2 |pages= 221–5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Vourc'h P, Martin I, Bonnet-Brilhault F, "et al." |title=Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. |journal=Psychiatr. Genet. |volume=13 |issue= 4 |pages= 221–5 |year= 2005 |pmid= 14639049 |doi= 10.1097/01.ypg.0000084946.07075.37
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bartee E, Mansouri M, Hovey Nerenberg BT, "et al." |title=Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. |journal=J. Virol. |volume=78 |issue= 3 |pages= 1109–20 |year= 2004 |pmid= 14722266 |doi=
*cite journal | author=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495–502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066
*cite journal | author=Kim HJ, Chong KH, Kang SW, "et al." |title=Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening. |journal=Immunol. Lett. |volume=95 |issue= 2 |pages= 155–9 |year= 2005 |pmid= 15388255 |doi= 10.1016/j.imlet.2004.07.001
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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