MAFK

V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian), also known as MAFK, is a human gene.cite web | title = Entrez Gene: MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7975| accessdate = ]

PBB_Summary
section_title =
summary_text = The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites. [supplied by OMIM] cite web | title = Entrez Gene: MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7975| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ney PA, Andrews NC, Jane SM, "et al." |title=Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. |journal=Mol. Cell. Biol. |volume=13 |issue= 9 |pages= 5604–12 |year= 1993 |pmid= 8355703 |doi=
*cite journal | author=Oyake T, Itoh K, Motohashi H, "et al." |title=Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6083–95 |year= 1996 |pmid= 8887638 |doi=
*cite journal | author=Toki T, Itoh J, Kitazawa J, "et al." |title=Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. |journal=Oncogene |volume=14 |issue= 16 |pages= 1901–10 |year= 1997 |pmid= 9150357 |doi= 10.1038/sj.onc.1201024
*cite journal | author=Iwata T, Kogame K, Toki T, "et al." |title=Structure and chromosome mapping of the human small maf-genes MAFG and MAFK. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 1-2 |pages= 88–90 |year= 1998 |pmid= 9763667 |doi=
*cite journal | author=Quevillon S, Robinson JC, Berthonneau E, "et al." |title=Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 183–95 |year= 1999 |pmid= 9878398 |doi= 10.1006/jmbi.1998.2316
*cite journal | author=Kobayashi A, Ito E, Toki T, "et al." |title=Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6443–52 |year= 1999 |pmid= 10037736 |doi=
*cite journal | author=Nguyen T, Huang HC, Pickett CB |title=Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15466–73 |year= 2000 |pmid= 10747902 |doi= 10.1074/jbc.M000361200
*cite journal | author=Dhakshinamoorthy S, Jaiswal AK |title=Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40134–41 |year= 2001 |pmid= 11013233 |doi= 10.1074/jbc.M003531200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097–101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

External links

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