NEK9

NIMA (never in mitosis gene a)- related kinase 9
Identifiers
Symbols	NEK9; DKFZp434D0935; MGC138306; MGC16714; NERCC; NERCC1; Nek8
External IDs	OMIM: 609798 MGI: 2387995 HomoloGene: 13222 GeneCards: NEK9 Gene
EC number	2.7.11.1
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding • metal ion binding Cellular component • nucleus • cytoplasm • mitochondrion Biological process • cell cycle • mitosis • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	91754	217718
Ensembl	ENSG00000119638	ENSMUSG00000034290
UniProt	Q8TD19	Q148U2
RefSeq (mRNA)	NM_033116	NM_145138.2
RefSeq (protein)	NP_149107	NP_660120.2
Location (UCSC)	Chr 14: 75.55 – 75.59 Mb	Chr 12: 86.64 – 86.68 Mb
PubMed search	[1]	[2]

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.^[1][2]

Interactions

NEK9 has been shown to interact with Structure specific recognition protein 1,^[3] NEK6^[4][5][6] and Ran (biology).^[6]

References

1. ^ Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD (Apr 2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". J Biol Chem 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968. 
2. ^ "Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91754. 
3. ^ Tan, Bertrand Chin-Ming; Lee Sheng-Chung (Mar. 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. (United States) 279 (10): 9321–30. doi:10.1074/jbc.M311477200. ISSN 0021-9258. PMID 14660563. 
4. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
5. ^ Belham, Christopher; Roig Joan, Caldwell Jennifer A, Aoyama Yumi, Kemp Bruce E, Comb Michael, Avruch Joseph (Sep. 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. (United States) 278 (37): 34897–909. doi:10.1074/jbc.M303663200. ISSN 0021-9258. PMID 12840024. 
6. ^ ^{a b} Roig, Joan; Mikhailov Alexei, Belham Christopher, Avruch Joseph (Jul. 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. (United States) 16 (13): 1640–58. doi:10.1101/gad.972202. ISSN 0890-9369. PMC 186374. PMID 12101123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186374. 

Further reading

• Pelka P, Scimè A, Mandalfino C, et al. (2007). "Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase.". J. Cell. Physiol. 212 (1): 13–25. doi:10.1002/jcp.20983. PMID 17443675. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Bowers AJ, Boylan JF (2004). "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.". Gene 328: 135–42. doi:10.1016/j.gene.2003.12.002. PMID 15019993. 
• Tan BC, Lee SC (2004). "Nek9, a novel FACT-associated protein, modulates interphase progression.". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563. 
• Belham C, Roig J, Caldwell JA, et al. (2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024. 
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Roig J, Mikhailov A, Belham C, Avruch J (2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374. PMID 12101123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186374. 
• Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.". DNA Res. 9 (2): 47–57. doi:10.1093/dnares/9.2.47. PMID 12056414.