ADAM2

ADAM2

ADAM metallopeptidase domain 2 (fertilin beta), also known as ADAM2, is a human gene.cite web | title = Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.cite web | title = Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Eto K, Huet C, Tarui T, "et al." |title=Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17804–10 |year= 2002 |pmid= 11882657 |doi= 10.1074/jbc.M200086200
*cite journal | author=Ikawa M, Nakanishi T, Yamada S, "et al." |title=Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. |journal=Dev. Biol. |volume=240 |issue= 1 |pages= 254–61 |year= 2002 |pmid= 11784061 |doi= 10.1006/dbio.2001.0462
*cite journal | author=Cho C, Ge H, Branciforte D, "et al." |title=Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion. |journal=Dev. Biol. |volume=222 |issue= 2 |pages= 289–95 |year= 2000 |pmid= 10837118 |doi= 10.1006/dbio.2000.9703
*cite journal | author=Chen MS, Tung KS, Coonrod SA, "et al." |title=Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11830–5 |year= 1999 |pmid= 10518536 |doi=
*cite journal | author=Chen H, Sampson NS |title=Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta. |journal=Chem. Biol. |volume=6 |issue= 1 |pages= 1–10 |year= 1999 |pmid= 9889149 |doi= 10.1016/S1074-5521(99)80015-5
*cite journal | author=Burkin HR, Burkin DJ, Davey PM, "et al." |title=Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB). |journal=Genomics |volume=40 |issue= 1 |pages= 190–2 |year= 1997 |pmid= 9070941 |doi= 10.1006/geno.1996.4531
*cite journal | author=Vidaeus CM, von Kapp-Herr C, Golden WL, "et al." |title=Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member. |journal=Mol. Reprod. Dev. |volume=46 |issue= 3 |pages= 363–9 |year= 1997 |pmid= 9041139 |doi= 10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-# |doilabel=10.1002/(SICI)1098-2795(199703)46:3363::AID-MRD153.0.CO;2-#
*cite journal | author=Gupta SK, Alves K, Palladino LO, "et al." |title=Molecular cloning of the human fertilin beta subunit. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 2 |pages= 318–26 |year= 1996 |pmid= 8702389 |doi= 10.1006/bbrc.1996.1027
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=

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