GABRE

GABRE

Gamma-aminobutyric acid (GABA) A receptor, epsilon, also known as GABRE, is a human gene.cite web | title = Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2564| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2564| accessdate = ]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jones BL, Henderson LP |title=Trafficking and potential assembly patterns of epsilon-containing GABAA receptors. |journal=J. Neurochem. |volume=103 |issue= 3 |pages= 1258–71 |year= 2007 |pmid= 17714454 |doi= 10.1111/j.1471-4159.2007.04833.x
*cite journal | author=Rosen A, Bali M, Horenstein J, Akabas MH |title=Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment. |journal=Biophys. J. |volume=92 |issue= 9 |pages= 3130–9 |year= 2007 |pmid= 17293408 |doi= 10.1529/biophysj.106.094490
*cite journal | author=Wilkins ME, Hosie AM, Smart TG |title=Proton modulation of recombinant GABA(A) receptors: influence of GABA concentration and the beta subunit TM2-TM3 domain. |journal=J. Physiol. (Lond.) |volume=567 |issue= Pt 2 |pages= 365–77 |year= 2005 |pmid= 15946973 |doi= 10.1113/jphysiol.2005.088823
*cite journal | author=Porter BE, Zhang G, Celix J, "et al." |title=Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. |journal=Neurobiol. Dis. |volume=18 |issue= 3 |pages= 484–91 |year= 2005 |pmid= 15755675 |doi= 10.1016/j.nbd.2004.12.010
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Davies PA, McCartney MR, Wang W, "et al." |title=Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat. |journal=Neuropharmacology |volume=43 |issue= 4 |pages= 467–75 |year= 2002 |pmid= 12367593 |doi=
*cite journal | author=Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER |title=GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. |journal=J. Neurosci. |volume=20 |issue= 10 |pages= 3588–95 |year= 2000 |pmid= 10804200 |doi=
*cite journal | author=Russek SJ |title=Evolution of GABA(A) receptor diversity in the human genome. |journal=Gene |volume=227 |issue= 2 |pages= 213–22 |year= 1999 |pmid= 10023064 |doi=
*cite journal | author=Wilke K, Gaul R, Klauck SM, Poustka A |title=A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor. |journal=Genomics |volume=45 |issue= 1 |pages= 1–10 |year= 1997 |pmid= 9339354 |doi= 10.1006/geno.1997.4885
*cite journal | author=Whiting PJ, McAllister G, Vassilatis D, "et al." |title=Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published] |journal=J. Neurosci. |volume=17 |issue= 13 |pages= 5027–37 |year= 1997 |pmid= 9185540 |doi=
*cite journal | author=Garret M, Bascles L, Boue-Grabot E, "et al." |title=An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system. |journal=J. Neurochem. |volume=68 |issue= 4 |pages= 1382–9 |year= 1997 |pmid= 9084408 |doi=
*cite journal | author=Davies PA, Hanna MC, Hales TG, Kirkness EF |title=Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. |journal=Nature |volume=385 |issue= 6619 |pages= 820–3 |year= 1997 |pmid= 9039914 |doi= 10.1038/385820a0

External links

*

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