P2RX3

P2RX3
Purinergic receptor P2X, ligand-gated ion channel, 3
Identifiers
Symbols P2RX3; MGC129956; P2X3
External IDs OMIM600843 MGI1097160 HomoloGene1922 GeneCards: P2RX3 Gene
Orthologs
Species Human Mouse
Entrez 5024 228139
Ensembl ENSG00000109991 ENSMUSG00000027071
UniProt P56373 Q3UR32
RefSeq (mRNA) XM_001126192 NM_145526
RefSeq (protein) XP_001126192 NP_663501.2
Location (UCSC) Chr 11:
57.11 – 57.14 Mb
Chr 2:
84.84 – 84.88 Mb
PubMed search [1] [2]

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.[2]

Contents

See also

References

  1. ^ Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902. 
  2. ^ a b "Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5024. 

Further reading

External links

Ionotropic glutamates ATP-gated channels B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Look at other dictionaries:

  • P2X purinoreceptor — ATP P2X receptor Identifiers Symbol P2X receptor Pfam PF00864 InterPro …   Wikipedia

  • Ligand-gated ion channel — Neurotransmitter gated ion channel transmembrane region Ligand gated ion channel Identifiers Symbol Neur chan memb Pfam …   Wikipedia

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