KCNQ5

KCNQ5

Potassium voltage-gated channel, KQT-like subfamily, member 5, also known as KCNQ5, is a human gene.cite web | title = Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56479| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.cite web | title = Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56479| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Lerche C, Scherer CR, Seebohm G, "et al." |title=Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22395–400 |year= 2000 |pmid= 10787416 |doi= 10.1074/jbc.M002378200
*cite journal | author=Schroeder BC, Hechenberger M, Weinreich F, "et al." |title=KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24089–95 |year= 2000 |pmid= 10816588 |doi= 10.1074/jbc.M003245200
*cite journal | author=Wickenden AD, Zou A, Wagoner PK, Jegla T |title=Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. |journal=Br. J. Pharmacol. |volume=132 |issue= 2 |pages= 381–4 |year= 2001 |pmid= 11159685 |doi= 10.1038/sj.bjp.0703861
*cite journal | author=Yus-Najera E, Santana-Castro I, Villarroel A |title=The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28545–53 |year= 2002 |pmid= 12032157 |doi= 10.1074/jbc.M204130200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ozeki Y, Tomoda T, Kleiderlein J, "et al." |title=Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 1 |pages= 289–94 |year= 2003 |pmid= 12506198 |doi= 10.1073/pnas.0136913100
*cite journal | author=Yus-Nájera E, Muñoz A, Salvador N, "et al." |title=Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation. |journal=Neuroscience |volume=120 |issue= 2 |pages= 353–64 |year= 2003 |pmid= 12890507 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Li Y, Langlais P, Gamper N, "et al." |title=Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 45399–407 |year= 2004 |pmid= 15304482 |doi= 10.1074/jbc.M408410200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jensen HS, Grunnet M, Olesen SP |title=Inactivation as a new regulatory mechanism for neuronal Kv7 channels. |journal=Biophys. J. |volume=92 |issue= 8 |pages= 2747–56 |year= 2007 |pmid= 17237198 |doi= 10.1529/biophysj.106.101287

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