UBE1L

Ubiquitin-activating enzyme E1-like, also known as UBE1L, is a human gene.cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Carritt B, Kok K, van den Berg A, "et al." |title=A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. |journal=Cancer Res. |volume=52 |issue= 6 |pages= 1536–41 |year= 1992 |pmid= 1311632 |doi=
*cite journal | author=Kok K, Van den Berg A, Veldhuis PM, "et al." |title=The genomic structure of the human UBE1L gene. |journal=Gene Expr. |volume=4 |issue= 3 |pages= 163–75 |year= 1995 |pmid= 7734949 |doi=
*cite journal | author=Kok K, Hofstra R, Pilz A, "et al." |title=A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6071–5 |year= 1993 |pmid= 8327486 |doi=
*cite journal | author=McLaughlin PM, Helfrich W, Kok K, "et al." |title=The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. |journal=Int. J. Cancer |volume=85 |issue= 6 |pages= 871–6 |year= 2000 |pmid= 10709110 |doi=
*cite journal | author=Yuan W, Krug RM |title=Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. |journal=EMBO J. |volume=20 |issue= 3 |pages= 362–71 |year= 2001 |pmid= 11157743 |doi= 10.1093/emboj/20.3.362
*cite journal | author=Kitareewan S, Pitha-Rowe I, Sekula D, "et al." |title=UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3806–11 |year= 2002 |pmid= 11891284 |doi= 10.1073/pnas.052011299
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Pitha-Rowe I, Hassel BA, Dmitrovsky E |title=Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18178–87 |year= 2004 |pmid= 14976209 |doi= 10.1074/jbc.M309259200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lenschow DJ, Giannakopoulos NV, Gunn LJ, "et al." |title=Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. |journal=J. Virol. |volume=79 |issue= 22 |pages= 13974–83 |year= 2006 |pmid= 16254333 |doi= 10.1128/JVI.79.22.13974-13983.2005
*cite journal | author=Takeuchi T, Iwahara S, Saeki Y, "et al." |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711–9 |year= |pmid= 16428300 |doi= 10.1093/jb/mvi172

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