SIRPB1

Signal-regulatory protein beta 1, also known as SIRPB1, is a human gene. SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.cite web | title = Entrez Gene: SIRPB1 signal-regulatory protein beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10326| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kharitonenkov A, Chen Z, Sures I, "et al." |title=A family of proteins that inhibit signalling through tyrosine kinase receptors. |journal=Nature |volume=386 |issue= 6621 |pages= 181–6 |year= 1997 |pmid= 9062191 |doi= 10.1038/386181a0
*cite journal | author=Dietrich J, Cella M, Seiffert M, "et al." |title=Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. |journal=J. Immunol. |volume=164 |issue= 1 |pages= 9–12 |year= 2000 |pmid= 10604985 |doi=
*cite journal | author=Tomasello E, Cant C, Bühring HJ, "et al." |title=Association of signal-regulatory proteins beta with KARAP/DAP-12. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2147–56 |year= 2000 |pmid= 10940905 |doi=10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Cannon JP, Haire RN, Litman GW |title=Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1200–7 |year= 2002 |pmid= 12415263 |doi= 10.1038/ni849
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liu Y, Soto I, Tong Q, "et al." |title=SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36132–40 |year= 2006 |pmid= 16081415 |doi= 10.1074/jbc.M506419200
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=van den Berg TK, van Beek EM, Bühring HJ, "et al." |title=A nomenclature for signal regulatory protein family members. |journal=J. Immunol. |volume=175 |issue= 12 |pages= 7788–9 |year= 2006 |pmid= 16339511 |doi=

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