Kua-UEV

Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.cite web | title = Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387522| accessdate = ]

PBB_Summary
section_title =
summary_text = The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined.cite web | title = Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387522| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Long M |title=A new function evolved from gene fusion. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1655–7 |year= 2001 |pmid= 11076848 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Rothofsky ML, Lin SL |title=CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. |journal=Gene |volume=195 |issue= 2 |pages= 141–9 |year= 1997 |pmid= 9305758 |doi=
*cite journal | author=Sancho E, Vilá MR, Sánchez-Pulido L, "et al." |title=Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 576–89 |year= 1998 |pmid= 9418904 |doi=
*cite journal | author=Xiao W, Lin SL, Broomfield S, "et al." |title=The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3908–14 |year= 1998 |pmid= 9705497 |doi=
*cite journal | author=Ma L, Broomfield S, Lavery C, "et al." |title=Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. |journal=Oncogene |volume=17 |issue= 10 |pages= 1321–6 |year= 1998 |pmid= 9771976 |doi= 10.1038/sj.onc.1202058
*cite journal | author=Hofmann RM, Pickart CM |title=Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. |journal=Cell |volume=96 |issue= 5 |pages= 645–53 |year= 1999 |pmid= 10089880 |doi=
*cite journal | author=Deng L, Wang C, Spencer E, "et al." |title=Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. |journal=Cell |volume=103 |issue= 2 |pages= 351–61 |year= 2000 |pmid= 11057907 |doi=
*cite journal | author=Thomson TM, Lozano JJ, Loukili N, "et al." |title=Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1743–56 |year= 2001 |pmid= 11076860 |doi=
*cite journal | author=Dias DC, Dolios G, Wang R, Pan ZQ |title=CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16601–6 |year= 2003 |pmid= 12481031 |doi= 10.1073/pnas.252646399
*cite journal | author=Guo D, Han J, Adam BL, "et al." |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191

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