NUP85

Nucleoporin 85kDa
Identifiers
Symbols	NUP85; FLJ12549; Nup75
External IDs	OMIM: 170285 MGI: 3046173 HomoloGene: 11755 GeneCards: NUP85 Gene
Gene Ontology Molecular function • protein binding Cellular component • kinetochore • condensed chromosome kinetochore • nucleus • nuclear envelope • nuclear envelope • chromosome • cytoplasm • spindle • cytosol • cytoskeleton • membrane • Nup107-160 complex • Nup107-160 complex • nuclear membrane Biological process • M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • carbohydrate metabolic process • chemotaxis • hexose transport • regulation of glucose transport • protein transport • glucose transport • viral reproduction • lamellipodium assembly • macrophage chemotaxis • mRNA transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79902	445007
Ensembl	ENSG00000125450	ENSMUSG00000020739
UniProt	Q9BW27	n/a
RefSeq (mRNA)	NM_024844	NM_001002929.4
RefSeq (protein)	NP_079120	NP_001002929.3
Location (UCSC)	Chr 17: 73.2 – 73.23 Mb	Chr 11: 115.43 – 115.45 Mb
PubMed search	[1]	[2]

Nucleoporin NUP85 is a protein that in humans is encoded by the NUP85 gene.^[1][2]

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.^[2]

References

1. ^ Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Apr 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. 
2. ^ ^{a b} "Entrez Gene: NUP85 nucleoporin 85kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79902. 

Further reading

• Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.". J. Biol. Chem. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789. 
• Tynan SH, Purohit A, Doxsey SJ, Vallee RB (2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin.". J. Biol. Chem. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222. 
• Cronshaw JM, Krutchinsky AN, Zhang W, et al. (2002). "Proteomic analysis of the mammalian nuclear pore complex.". J. Cell Biol. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173148. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Mulari MT, Patrikainen L, Kaisto T, et al. (2003). "The architecture of microtubular network and Golgi orientation in osteoclasts--major differences between avian and mammalian species.". Exp. Cell Res. 285 (2): 221–35. doi:10.1016/S0014-4827(03)00033-8. PMID 12706117. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.". Mol. Biol. Cell 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=379276. 
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452587. 
• Terashima Y, Onai N, Murai M, et al. (2005). "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.". Nat. Immunol. 6 (8): 827–35. doi:10.1038/ni1222. PMID 15995708. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Satoh M, Akatsu T, Ishkawa Y, et al. (2007). "A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart.". J. Card. Fail. 13 (2): 114–9. doi:10.1016/j.cardfail.2006.11.003. PMID 17395051.