Cyclin K

Cyclin K
PDB rendering based on 2i53.
Available structures PDB 2i53
Identifiers
Symbols	CCNK; CPR4; MGC9113
External IDs	OMIM: 603544 HomoloGene: 14748 GeneCards: CCNK Gene
Gene Ontology Molecular function • protein binding • protein kinase binding Biological process • regulation of cyclin-dependent protein kinase activity • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • cell cycle • mitosis • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8812	12454
Ensembl	ENSG00000090061	ENSMUSG00000021258
UniProt	O75909	n/a
RefSeq (mRNA)	NM_003858	NM_009832.2
RefSeq (protein)	NP_003849	NP_033962.2
Location (UCSC)	Chr 14: 99.95 – 99.98 Mb	Chr 12: 109.42 – 109.44 Mb
PubMed search	[1]	[2]

Cyclin-K is a protein that in humans is encoded by the CCNK gene.^[1][2][3]

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.^[3]

Interactions

Cyclin K has been shown to interact with CDK9.^[2]

References

1. ^ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity". Mol Cell Biol 18 (7): 4291–300. PMC 109013. PMID 9632813. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109013. 
2. ^ ^{a b} Fu TJ, Peng J, Lee G, Price DH, Flores O (Feb 2000). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". J Biol Chem 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912. 
3. ^ ^{a b} "Entrez Gene: CCNK cyclin K". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8812. 

Further reading

• Lin X, Taube R, Fujinaga K, Peterlin BM (2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". J. Biol. Chem. 277 (19): 16873–8. doi:10.1074/jbc.M200117200. PMID 11884399. 
• Mori T, Anazawa Y, Matsui K et al. (2002). "Cyclin K as a Direct Transcriptional Target of the p53 Tumor Suppressor". Neoplasia 4 (3): 268–74. doi:10.1038/sj/neo/7900235. PMC 1531701. PMID 11988847. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1531701. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Baek K, Brown RS, Birrane G, Ladias JA (2007). "Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9". J. Mol. Biol. 366 (2): 563–73. doi:10.1016/j.jmb.2006.11.057. PMC 1852425. PMID 17169370. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1852425.