GLIPR1


GLIPR1

GLI pathogenesis-related 1 (glioma), also known as GLIPR1, is a human gene.cite web | title = Entrez Gene: GLIPR1 GLI pathogenesis-related 1 (glioma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11010| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: GLIPR1 GLI pathogenesis-related 1 (glioma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11010| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Murphy EV, Zhang Y, Zhu W, Biggs J |title=The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. |journal=Gene |volume=159 |issue= 1 |pages= 131–5 |year= 1995 |pmid= 7607567 |doi=
*cite journal | author=Rich T, Chen P, Furman F, "et al." |title=RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin. |journal=Gene |volume=180 |issue= 1-2 |pages= 125–30 |year= 1997 |pmid= 8973356 |doi=
*cite journal | author=Szyperski T, Fernández C, Mumenthaler C, Wüthrich K |title=Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2262–6 |year= 1998 |pmid= 9482873 |doi=
*cite journal | author=Gingras MC, Margolin JF |title=Differential expression of multiple unexpected genes during U937 cell and macrophage differentiation detected by suppressive subtractive hybridization. |journal=Exp. Hematol. |volume=28 |issue= 3 |pages= 350 |year= 2000 |pmid= 10720702 |doi=
*cite journal | author=Ren C, Li L, Goltsov AA, "et al." |title=mRTVP-1, a novel p53 target gene with proapoptotic activities. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3345–57 |year= 2002 |pmid= 11971968 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ren C, Li L, Yang G, "et al." |title=RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. |journal=Cancer Res. |volume=64 |issue= 3 |pages= 969–76 |year= 2004 |pmid= 14871827 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ren C, Ren CH, Li L, "et al." |title=Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. |journal=Genomics |volume=88 |issue= 2 |pages= 163–72 |year= 2006 |pmid= 16714093 |doi= 10.1016/j.ygeno.2006.03.021
*cite journal | author=Xiang C, Sarid R, Cazacu S, "et al." |title=Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells. |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 3 |pages= 612–8 |year= 2007 |pmid= 17825796 |doi= 10.1016/j.bbrc.2007.08.138
*cite journal | author=Chilukamarri L, Hancock AL, Malik S, "et al." |title=Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors. |journal=Neoplasia |volume=9 |issue= 11 |pages= 970–8 |year= 2007 |pmid= 18030365 |doi=

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