LECT1

LECT1

Leukocyte cell derived chemotaxin 1, also known as LECT1, is a human gene.cite web | title = Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11061| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11061| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hiraki Y, Shukunami C |title=Chondromodulin-I as a novel cartilage-specific growth-modulating factor. |journal=Pediatr. Nephrol. |volume=14 |issue= 7 |pages= 602–5 |year= 2000 |pmid= 10912526 |doi=
*cite journal | author=Shukunami C, Hiraki Y |title=Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=249 |issue= 3 |pages= 885–90 |year= 1998 |pmid= 9731231 |doi= 10.1006/bbrc.1998.9233
*cite journal | author=Hiraki Y, Mitsui K, Endo N, "et al." |title=Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells. |journal=Eur. J. Biochem. |volume=260 |issue= 3 |pages= 869–78 |year= 1999 |pmid= 10103018 |doi=
*cite journal | author=Hayami T, Shukunami C, Mitsui K, "et al." |title=Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo. |journal=FEBS Lett. |volume=458 |issue= 3 |pages= 436–40 |year= 2000 |pmid= 10570955 |doi=
*cite journal | author=Yanagihara I, Yamagata M, Sakai N, "et al." |title=Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells. |journal=J. Bone Miner. Res. |volume=15 |issue= 3 |pages= 421–9 |year= 2000 |pmid= 10750556 |doi=
*cite journal | author=Azizan A, Holaday N, Neame PJ |title=Post-translational processing of bovine chondromodulin-I. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23632–8 |year= 2001 |pmid= 11323410 |doi= 10.1074/jbc.M009967200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Aoyama T, Okamoto T, Nagayama S, "et al." |title=Expression of the chondromodulin-I gene in chondrosarcomas. |journal=Cancer Lett. |volume=204 |issue= 1 |pages= 61–8 |year= 2004 |pmid= 14744535 |doi=
*cite journal | author=Aoyama T, Okamoto T, Nagayama S, "et al." |title=Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28789–97 |year= 2004 |pmid= 15107420 |doi= 10.1074/jbc.M401273200
*cite journal | author=Yoshioka M, Yuasa S, Matsumura K, "et al." |title=Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. |journal=Nat. Med. |volume=12 |issue= 10 |pages= 1151–9 |year= 2006 |pmid= 16980969 |doi= 10.1038/nm1476

PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


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