CD160

CD160 molecule, also known as CD160, is a human gene.cite web | title = Entrez Gene: CD160 CD160 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11126| accessdate = ]

PBB_Summary
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summary_text = CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.cite web | title = Entrez Gene: CD160 CD160 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11126| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bensussan A, Gluckman E, el Marsafy S, "et al." |title=BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 19 |pages= 9136–40 |year= 1994 |pmid= 8090781 |doi=
*cite journal | author=Anumanthan A, Bensussan A, Boumsell L, "et al." |title=Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. |journal=J. Immunol. |volume=161 |issue= 6 |pages= 2780–90 |year= 1998 |pmid= 9743336 |doi=
*cite journal | author=Agrawal S, Marquet J, Freeman GJ, "et al." |title=Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |journal=J. Immunol. |volume=162 |issue= 3 |pages= 1223–6 |year= 1999 |pmid= 9973372 |doi=
*cite journal | author=Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A |title=BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression. |journal=Int. Immunol. |volume=14 |issue= 5 |pages= 445–51 |year= 2002 |pmid= 11978774 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tanaka J, Toubai T, Tsutsumi Y, "et al." |title=Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. |journal=Blood |volume=104 |issue= 3 |pages= 768–74 |year= 2004 |pmid= 15073036 |doi= 10.1182/blood-2003-11-3870
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Barakonyi A, Rabot M, Marie-Cardine A, "et al." |title=Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset. |journal=J. Immunol. |volume=173 |issue= 9 |pages= 5349–54 |year= 2004 |pmid= 15494480 |doi=
*cite journal | author=Abecassis S, Giustiniani J, Meyer N, "et al." |title=Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation. |journal=J. Invest. Dermatol. |volume=127 |issue= 5 |pages= 1161–6 |year= 2007 |pmid= 17218942 |doi= 10.1038/sj.jid.5700680
*cite journal | author=Giustiniani J, Marie-Cardine A, Bensussan A |title=A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity. |journal=J. Immunol. |volume=178 |issue= 3 |pages= 1293–300 |year= 2007 |pmid= 17237375 |doi=

External links

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