NCAPH

Non-SMC condensin I complex, subunit H
Identifiers
Symbols	NCAPH; BRRN1; CAP-H; HCAP-H
External IDs	OMIM: 602332 MGI: 2444777 HomoloGene: 5320 GeneCards: NCAPH Gene
Gene Ontology Cellular component • condensin complex • nucleus • chromosome • cytoplasm • microtubule cytoskeleton Biological process • cell cycle • mitosis • mitotic chromosome condensation • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23397	215387
Ensembl	ENSG00000121152	ENSMUSG00000034906
UniProt	Q15003	Q6ZQJ9
RefSeq (mRNA)	NM_015341	NM_144818.3
RefSeq (protein)	NP_056156	NP_659067.2
Location (UCSC)	Chr 2: 97 – 97.04 Mb	Chr 2: 126.93 – 126.96 Mb
PubMed search	[1]	[2]

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene.^[1][2] CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation

Function

CAP-H is a member of the barr protein family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. CAP-H is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.^[2]

References

1. ^ Cabello OA, Baldini A, Bhat M, Bellen H, Belmont JW (Feb 1998). "Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2". Genomics 46 (2): 311–3. doi:10.1006/geno.1997.5021. PMID 9417923. 
2. ^ ^{a b} "Entrez Gene: NCAPH non-SMC condensin I complex, subunit H". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23397. 

Further reading

• Nomura N, Nagase T, Miyajima N et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044. 
• Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein". Cell 89 (4): 511–21. doi:10.1016/S0092-8674(00)80233-0. PMID 9160743. 
• Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719. 
• Cabello OA, Eliseeva E, He WG et al. (2002). "Cell Cycle-dependent Expression and Nucleolar Localization of hCAP-H". Mol. Biol. Cell 12 (11): 3527–37. PMC 60273. PMID 11694586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60273. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Heale JT, Ball AR, Schmiesing JA et al. (2006). "Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair". Mol. Cell 21 (6): 837–48. doi:10.1016/j.molcel.2006.01.036. PMID 16543152. 
• Nousiainen M, Silljé HH, Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365. 
• Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.