- HEYL
Hairy/enhancer-of-split related with YRPW motif-like, also known as HEYL, is a human
gene .cite web | title = Entrez Gene: HEYL hairy/enhancer-of-split related with YRPW motif-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26508| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.cite web | title = Entrez Gene: HEYL hairy/enhancer-of-split related with YRPW motif-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26508| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Iso T, Kedes L, Hamamori Y |title=HES and HERP families: multiple effectors of the Notch signaling pathway. |journal=J. Cell. Physiol. |volume=194 |issue= 3 |pages= 237–55 |year= 2003 |pmid= 12548545 |doi= 10.1002/jcp.10208
*cite journal | author=Kokubo H, Miyagawa-Tomita S, Johnson RL |title=Hesr, a mediator of the Notch signaling, functions in heart and vessel development. |journal=Trends Cardiovasc. Med. |volume=15 |issue= 5 |pages= 190–4 |year= 2006 |pmid= 16165016 |doi= 10.1016/j.tcm.2005.05.005
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Leimeister C, Externbrink A, Klamt B, Gessler M |title=Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. |journal=Mech. Dev. |volume=85 |issue= 1-2 |pages= 173–7 |year= 1999 |pmid= 10415358 |doi=
*cite journal | author=Steidl C, Leimeister C, Klamt B, "et al." |title=Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. |journal=Genomics |volume=66 |issue= 2 |pages= 195–203 |year= 2000 |pmid= 10860664 |doi= 10.1006/geno.2000.6200
*cite journal | author=Firulli BA, Hadzic DB, McDaid JR, Firulli AB |title=The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33567–73 |year= 2000 |pmid= 10924525 |doi= 10.1074/jbc.M005888200
*cite journal | author=Nakagawa O, McFadden DG, Nakagawa M, "et al." |title=Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13655–60 |year= 2001 |pmid= 11095750 |doi= 10.1073/pnas.250485597
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209External links
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PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
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