ANAPC4

Anaphase promoting complex subunit 4, also known as ANAPC4, is a human gene.cite web | title = Entrez Gene: ANAPC4 anaphase promoting complex subunit 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29945| accessdate = ]

PBB_Summary
section_title =
summary_text = A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.cite web | title = Entrez Gene: ANAPC4 anaphase promoting complex subunit 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29945| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tekolf WA, Biddison WE, Aster RD, Shaw S |title=Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium. |journal=J. Immunol. |volume=129 |issue= 4 |pages= 1474–8 |year= 1982 |pmid= 6180011 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yu H, Peters JM, King RW, "et al." |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=
*cite journal | author=Grossberger R, Gieffers C, Zachariae W, "et al." |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=
*cite journal | author=Gieffers C, Peters BH, Kramer ER, "et al." |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=
*cite journal | author=Gmachl M, Gieffers C, Podtelejnikov AV, "et al." |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, "et al." |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=
*cite journal | author=Kraft C, Herzog F, Gieffers C, "et al." |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598–609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627
*cite journal | author=Johnson JM, Castle J, Garrett-Engele P, "et al." |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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