PCDHA12

PCDHA12
Protocadherin alpha 12
Identifiers
Symbols PCDHA12; MGC138485; MGC141932; PCDH-ALPHA12
External IDs OMIM606318 HomoloGene88800 GeneCards: PCDHA12 Gene
Orthologs
Species Human Mouse
Entrez 56137 12943
Ensembl ENSG00000251664 n/a
UniProt Q9UN75 n/a
RefSeq (mRNA) NM_018903.2 NM_009961.1
RefSeq (protein) NP_061726.1 NP_034091.1
Location (UCSC) Chr 5:
140.26 – 140.39 Mb
n/a
PubMed search [1] [2]

Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.[1][2]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[2]

References

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHA12 protocadherin alpha 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56137. 

Further reading