PAK6

PAK6
P21 protein (Cdc42/Rac)-activated kinase 6

PDB rendering based on 2c30.
Identifiers
Symbols PAK6; PAK5
External IDs OMIM608110 MGI2679420 HomoloGene23200 GeneCards: PAK6 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE PAK6 219461 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56924 214230
Ensembl ENSG00000137843 ENSMUSG00000074923
UniProt Q9NQU5 n/a
RefSeq (mRNA) NM_001128628.1 NM_001033254
RefSeq (protein) NP_001122100.1 NP_001028426
Location (UCSC) Chr 15:
40.51 – 40.57 Mb
Chr 2:
118.49 – 118.52 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene.[1][2]

This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.[2]

Interactions

PAK6 has been shown to interact with Androgen receptor.[1][3]

References

  1. ^ a b Yang F, Li X, Sharma M, Zarnegar M, Lim B, Sun Z (Apr 2001). "Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6". J Biol Chem 276 (18): 15345–53. doi:10.1074/jbc.M010311200. PMID 11278661. 
  2. ^ a b "Entrez Gene: PAK6 p21(CDKN1A)-activated kinase 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56924. 
  3. ^ Lee, Suzanne R; Ramos Sharon M, Ko Andrew, Masiello David, Swanson Kenneth D, Lu Michael L, Balk Steven P (Jan. 2002). "AR and ER interaction with a p21-activated kinase (PAK6)". Mol. Endocrinol. (United States) 16 (1): 85–99. doi:10.1210/me.16.1.85. ISSN 0888-8809. PMID 11773441. 

Further reading


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Look at other dictionaries:

  • Androgen receptor — Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks).[1] …   Wikipedia

  • Protein kinase domain — Pfam box Symbol = Pkinase Name = Protein kinase domain width = caption = Pfam= PF00069 InterPro= IPR000719 SMART= TyrKc PROSITE = PDOC00629 SCOP = 1apm TCDB = OPM family= OPM protein= 2bcj PDB=PDB3|1ctpE:44 298 PDB3|2erzE:44 298 PDB3|1fotA:87 341 …   Wikipedia

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