- BIRC6
Baculoviral IAP repeat-containing 6 (apollon), also known as BIRC6, is a human
gene .cite web | title = Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57448| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.cite web | title = Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57448| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Chen Z, Naito M, Hori S, "et al." |title=A human IAP-family gene, apollon, expressed in human brain cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 3 |pages= 847–54 |year= 1999 |pmid= 10544019 |doi= 10.1006/bbrc.1999.1585
*cite journal | author=Nagase T, Ishikawa K, Kikuno R, "et al." |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Qiu XB, Markant SL, Yuan J, Goldberg AL |title=Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. |journal=EMBO J. |volume=23 |issue= 4 |pages= 800–10 |year= 2005 |pmid= 14765125 |doi= 10.1038/sj.emboj.7600075
*cite journal | author=Bartke T, Pohl C, Pyrowolakis G, Jentsch S |title=Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. |journal=Mol. Cell |volume=14 |issue= 6 |pages= 801–11 |year= 2005 |pmid= 15200957 |doi= 10.1016/j.molcel.2004.05.018
*cite journal | author=Hao Y, Sekine K, Kawabata A, "et al." |title=Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. |journal=Nat. Cell Biol. |volume=6 |issue= 9 |pages= 849–60 |year= 2004 |pmid= 15300255 |doi= 10.1038/ncb1159
*cite journal | author=Wu X, Yen L, Irwin L, "et al." |title=Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7748–57 |year= 2004 |pmid= 15314180 |doi= 10.1128/MCB.24.17.7748-7757.2004
*cite journal | author=Qiu XB, Goldberg AL |title=The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 174–82 |year= 2005 |pmid= 15507451 |doi= 10.1074/jbc.M411430200PBB_Controls
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