UBE4A

Ubiquitination factor E4A (UFD2 homolog, yeast), also known as UBE4A, is a human gene.cite web | title = Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9354| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.cite web | title = Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9354| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Koegl M, Hoppe T, Schlenker S, "et al." |title=A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. |journal=Cell |volume=96 |issue= 5 |pages= 635–44 |year= 1999 |pmid= 10089879 |doi=
*cite journal | author=Mahoney JA, Odin JA, White SM, "et al." |title=The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 587–95 |year= 2002 |pmid= 11802788 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Contino G, Amati F, Pucci S, "et al." |title=Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues. |journal=Gene |volume=328 |issue= |pages= 69–74 |year= 2004 |pmid= 15019985 |doi= 10.1016/j.gene.2003.11.017
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Spinette S, Lengauer C, Mahoney JA, "et al." |title=Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. |journal=Cell Cycle |volume=3 |issue= 12 |pages= 1638–44 |year= 2006 |pmid= 15611659 |doi=
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes