MMP24

Matrix metallopeptidase 24 (membrane-inserted), also known as MMP24, is a human gene.cite web | title = Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10893| accessdate = ]

PBB_Summary
section_title =
summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.cite web | title = Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10893| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491–4 |year= 1999 |pmid= 10419448 |doi=
*cite journal | author=Llano E, Pendás AM, Freije JP, "et al." |title=Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. |journal=Cancer Res. |volume=59 |issue= 11 |pages= 2570–6 |year= 1999 |pmid= 10363975 |doi=
*cite journal | author=Kinoh H, Hayashita H, Kajita M, "et al." |title=Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-->q12, respectively, by radiation hybrid and in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 97–8 |year= 2000 |pmid= 10640822 |doi=
*cite journal | author=Romanic AM, Burns-Kurtis CL, Ao Z, "et al." |title=Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients. |journal=Am. J. Physiol. Renal Physiol. |volume=281 |issue= 2 |pages= F309–17 |year= 2001 |pmid= 11457723 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jung M, Römer A, Keyszer G, "et al." |title=mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue. |journal=Prostate |volume=55 |issue= 2 |pages= 89–98 |year= 2003 |pmid= 12661033 |doi= 10.1002/pros.10194
*cite journal | author=Takino T, Koshikawa N, Miyamori H, "et al." |title=Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. |journal=Oncogene |volume=22 |issue= 30 |pages= 4617–26 |year= 2003 |pmid= 12879005 |doi= 10.1038/sj.onc.1206542
*cite journal | author=Wang P, Wang X, Pei D |title=Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20461–70 |year= 2004 |pmid= 14990567 |doi= 10.1074/jbc.M400264200
*cite journal | author=Gaetje R, Holtrich U, Engels K, "et al." |title=Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis. |journal=Gynecol. Endocrinol. |volume=23 |issue= 10 |pages= 567–73 |year= 2008 |pmid= 17952761 |doi= 10.1080/09513590701556921

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