OSBPL1A

Oxysterol binding protein-like 1A
Identifiers
Symbols	OSBPL1A; FLJ10217; ORP-1; ORP1; OSBPL1B
External IDs	OMIM: 606730 MGI: 1927551 HomoloGene: 84746 GeneCards: OSBPL1A Gene
Gene Ontology Molecular function • phospholipid binding Cellular component • intracellular Biological process • lipid transport • cholesterol metabolic process • vesicle-mediated transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	114876	64291
Ensembl	ENSG00000141447	ENSMUSG00000044252
UniProt	Q9BXW6	Q8K2D2
RefSeq (mRNA)	NM_001242508.1	NM_207530.2
RefSeq (protein)	NP_001229437.1	NP_997413.2
Location (UCSC)	Chr 18: 21.74 – 21.98 Mb	Chr 18: 12.91 – 13.1 Mb
PubMed search	[1]	[2]

Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene.^[1][2][3]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.^[3]

References

1. ^ Xu Y, Liu Y, Ridgway ND, McMaster CR (May 2001). "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport". J Biol Chem 276 (21): 18407–14. doi:10.1074/jbc.M101204200. PMID 11279184. 
2. ^ Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res 40 (12): 2204–11. PMID 10588946. 
3. ^ ^{a b} "Entrez Gene: OSBPL1A oxysterol binding protein-like 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114876. 

Further reading

• Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans.". J. Lipid Res. 42 (8): 1203–13. PMID 11483621. 
• Jaworski CJ, Moreira E, Li A, et al. (2002). "A family of 12 human genes containing oxysterol-binding domains.". Genomics 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Johansson M, Bocher V, Lehto M, et al. (2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.". Mol. Biol. Cell 14 (3): 903–15. doi:10.1091/mbc.E02-08-0459. PMC 151568. PMID 12631712. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151568. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Johansson M, Lehto M, Tanhuanpää K, et al. (2006). "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.". Mol. Biol. Cell 16 (12): 5480–92. doi:10.1091/mbc.E05-03-0189. PMC 1289395. PMID 16176980. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1289395. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.