DYNLL2

Dynein, light chain, LC8-type 2
PDB rendering based on 1cmi.
Available structures PDB 1cmi, 1f3c, 1f95, 1f96, 1pwj, 1pwk, 1re6, 1rhw, 2pg1
Identifiers
Symbols	DYNLL2; DNCL1B; Dlc2; MGC17810; RSPH22
External IDs	OMIM: 608942 MGI: 1915347 HomoloGene: 115597 GeneCards: DYNLL2 Gene
Gene Ontology Molecular function • motor activity • protein binding • cytoskeletal protein binding Cellular component • cytoplasm • centrosome • cytosol • cytoskeleton • microtubule • plasma membrane • myosin complex • dynein complex Biological process • transport • apoptosis • microtubule-based process • synaptic target recognition • induction of apoptosis by intracellular signals • activation of pro-apoptotic gene products Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	140735	68097
Ensembl	ENSG00000121083	ENSMUSG00000020483
UniProt	Q96FJ2	Q9D0M5
RefSeq (mRNA)	NM_080677	NM_026556
RefSeq (protein)	NP_542408	NP_080832
Location (UCSC)	Chr 17: 56.16 – 56.17 Mb	Chr 11: 87.79 – 87.8 Mb
PubMed search	[1]	[2]

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.^[1][2]

Interactions

DYNLL2 has been shown to interact with DLG4,^[3] DLGAP1,^[3] MYO5A^[3][4] and BMF.^[4][5]

References

1. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171247. 
2. ^ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140735. 
3. ^ ^{a b c} Naisbitt, S; Valtschanoff J, Allison D W, Sala C, Kim E, Craig A M, Weinberg R J, Sheng M (Jun. 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. (UNITED STATES) 20 (12): 4524–34. ISSN 0270-6474. PMID 10844022. 
4. ^ ^{a b} Puthalakath, H; Villunger A, O'Reilly L A, Beaumont J G, Coultas L, Cheney R E, Huang D C, Strasser A (Sep. 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science (United States) 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872. 
5. ^ Day, Catherine L; Puthalakath Hamsa, Skea Gretchen, Strasser Andreas, Barsukov Igor, Lian Lu-Yun, Huang David C S, Hinds Mark G (Feb. 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. (England) 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223895. 

Further reading

• Naisbitt S, Valtschanoff J, Allison DW, et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein.". J. Neurosci. 20 (12): 4524–34. PMID 10844022. 
• Haraguchi K, Satoh K, Yanai H, et al. (2001). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase.". Genes Cells 5 (11): 905–911. doi:10.1046/j.1365-2443.2000.00374.x. PMID 11122378. 
• Puthalakath H, Villunger A, O'Reilly LA, et al. (2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.". Science 293 (5536): 1829–32. doi:10.1126/science.1062257. PMID 11546872. 
• Fuhrmann JC, Kins S, Rostaing P, et al. (2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes.". J. Neurosci. 22 (13): 5393–402. PMID 12097491. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Day CL, Puthalakath H, Skea G, et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223895. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

DYNLL2 associations with risk for generalized anxiety disorder: Donner et al. An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders. Biological Psychiatry, 2008; 64 (8): 672 DOI: 10.1016/j.biopsych.2008.06.002