- PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, also known as PFKFB1, is a human
gene .cite web | title = Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5207| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.cite web | title = Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5207| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Lange AJ, Pilkis SJ |title=Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. |journal=Nucleic Acids Res. |volume=18 |issue= 12 |pages= 3652 |year= 1990 |pmid= 2163524 |doi=
*cite journal | author=Marker AJ, Colosia AD, Tauler A, "et al." |title=Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression. |journal=J. Biol. Chem. |volume=264 |issue= 12 |pages= 7000–4 |year= 1989 |pmid= 2540168 |doi=
*cite journal | author=Algaier J, Uyeda K |title=Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase. |journal=Biochem. Biophys. Res. Commun. |volume=153 |issue= 1 |pages= 328–33 |year= 1988 |pmid= 2837207 |doi=
*cite journal | author=Batra RS, Hatchwell E, Rider S, "et al." |title=Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21. |journal=Genomics |volume=40 |issue= 2 |pages= 358–61 |year= 1997 |pmid= 9119406 |doi= 10.1006/geno.1996.4530
*cite journal | author=Lee YH, Li Y, Uyeda K, Hasemann CA |title=Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 523–30 |year= 2003 |pmid= 12379646 |doi= 10.1074/jbc.M209105200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406PBB_Controls
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