M1G

Chembox new
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IUPACName = pyrimido [1,2-"a"] purin-10("3H")-one
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Section1 = Chembox Identifiers
CASNo=103408-45-3
PubChem=124218
SMILES=C1=CN2C(=O)C3=C(N=CN3)N=C2N=C1
Section2 = Chembox Properties
Formula=C₈H₅N₅O
MolarMass=187.1582
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Section3 = Chembox Hazards
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M₁G (pyrimido [1,2-"a"] purin-10("3H")-one) is a DNA adduct.cite journal | author = Seto H, Okuda T, Takesue T, Ikemura T | title = Reaction of Malonaldehyde with Nucleic Acid. I. Formation of Fluorescent Pyrimido [1,2-a] purin-10(3H)-one Nucleosides | journal = Bulletin of the Chemical Society of Japan | volume = 56 | issue = 6 | pages = 1799–1802 | year = 1983 | pmid = | doi = 10.1246/bcsj.56.1799 | url = | issn = ] It is created by malondialdehyde (an end product of lipid peroxidation) and is mutagenic. It is repaired by the body by the nucleotide excision repair system.cite journal | author = Marnett LJ | title = Lipid peroxidation-DNA damage by malondialdehyde | journal = Mutat. Res. | volume = 424 | issue = 1-2 | pages = 83–95 | year = 1999 | pmid = 10064852 | doi = 10.1016/S0027-5107(99)00010-X | url = | issn = ] If not repaired, the adduct is mutagenic. Therefore, detection and quantification of M₁G adducts in the body is a tool for diagnosing cancer.

It has been detected in cell DNA in liver, leucocytes, pancreas and breast in concentrations of 1-120 per 10⁸ nucleotides.

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