NDST2

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
Identifiers
Symbols	NDST2; HSST2; MGC129697; MGC129705; NST2
External IDs	OMIM: 603268 MGI: 97040 HomoloGene: 20803 GeneCards: NDST2 Gene
EC number	2.8.2.8
Gene Ontology Molecular function • sulfotransferase activity • [heparan sulfate-glucosamine N-sulfotransferase activity] • transferase activity • hydrolase activity Cellular component • Golgi membrane • Golgi apparatus • membrane • integral to membrane Biological process • cellular process • heparan sulfate proteoglycan biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8509	17423
Ensembl	ENSG00000166507	ENSMUSG00000039308
UniProt	P52849	P52850
RefSeq (mRNA)	NM_003635	NM_010811.2
RefSeq (protein)	NP_003626	NP_034941.2
Location (UCSC)	Chr 10: 75.56 – 75.57 Mb	Chr 14: 21.54 – 21.55 Mb
PubMed search	[1]	[2]

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.^[1][2]

References

1. ^ Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J 332 ( Pt 2): 303–7. PMC 1219482. PMID 9601056. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1219482. 
2. ^ "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8509. 

Further reading

• Esko JD, Selleck SB (2002). "Order out of chaos: assembly of ligand binding sites in heparan sulfate.". Annu. Rev. Biochem. 71: 435–71. doi:10.1146/annurev.biochem.71.110601.135458. PMID 12045103. 
• Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799. 
• Forsberg E, Pejler G, Ringvall M, et al. (1999). "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme.". Nature 400 (6746): 773–6. doi:10.1038/23488. PMID 10466727. 
• Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.". Biochemistry 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.". Glycobiology 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Duncan MB, Liu M, Fox C, Liu J (2006). "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2.". Biochem. Biophys. Res. Commun. 339 (4): 1232–7. doi:10.1016/j.bbrc.2005.11.142. PMID 16343444.