[cite journal | author = Born TL, Thomassen E, Bird TA, Sims JE | title = Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling | journal = J. Biol. Chem. | volume = 273 | issue = 45 | pages = 29445–50 | year = 1998 | month = November | pmid = 9792649 | doi = 10.1074/jbc.273.45.29445 | url = | issn = ] ]Function
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.
Disease association
Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[cite journal | author = Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA | title = Newly identified genetic risk variants for celiac disease related to the immune response | journal = Nat. Genet. | volume = 40 | issue = 4 | pages = 395–402 | year = 2008 | month = April | pmid = 18311140 | doi = 10.1038/ng.102 | url = | issn = ] ]ee also
* Interleukin-18 receptor
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Born TL, Thomassen E, Bird TA, Sims JE |title=Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29445–50 |year= 1998 |pmid= 9792649 |doi=
*cite journal | author=Sareneva T, Julkunen I, Matikainen S |title=IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. |journal=J. Immunol. |volume=165 |issue= 4 |pages= 1933–8 |year= 2000 |pmid= 10925275 |doi=
*cite journal | author=Mee JB, Alam Y, Groves RW |title=Human keratinocytes constitutively produce but do not process interleukin-18. |journal=Br. J. Dermatol. |volume=143 |issue= 2 |pages= 330–6 |year= 2000 |pmid= 10951141 |doi=
*cite journal | author=Debets R, Timans JC, Churakowa T, "et al." |title=IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18. |journal=J. Immunol. |volume=165 |issue= 9 |pages= 4950–6 |year= 2000 |pmid= 11046021 |doi=
*cite journal | author=Salvati VM, MacDonald TT, Bajaj-Elliott M, "et al." |title=Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. |journal=Gut |volume=50 |issue= 2 |pages= 186–90 |year= 2002 |pmid= 11788557 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fukushima K, Ikehara Y, Yamashita K |title=Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18056–62 |year= 2005 |pmid= 15760905 |doi= 10.1074/jbc.M413297200
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Fiszer D, Rozwadowska N, Rychlewski L, "et al." |title=Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues. |journal=Cytokine |volume=39 |issue= 3 |pages= 178–83 |year= 2008 |pmid= 17897836 |doi= 10.1016/j.cyto.2007.07.186
External links
*
PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes
