- TNFRSF1B
Tumor necrosis factor receptor superfamily, member 1B, also known as TNFRSF1B or CD120B, is a human
gene . The protein encoded by this gene is a member of theTumor necrosis factor receptor superfamily, which also contains TNFRSF1A. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [cite web | title = Entrez Gene: TNFRSF1B tumor necrosis factor receptor superfamily, member 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch= 7133 | accessdate = ]References
Further reading
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*cite journal | author=Kollias G, Kontoyiannis D |title=Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 315–21 |year= 2003 |pmid= 12220546 |doi=
*cite journal | author=Holtmann MH, Schuchmann M, Zeller G, "et al." |title=The emerging distinct role of TNF-receptor 2 (p80) signaling in chronic inflammatory disorders. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=50 |issue= 4 |pages= 279–88 |year= 2003 |pmid= 12371624 |doi=
*cite journal | author=Horiuchi T, Kiyohara C, Tsukamoto H, "et al." |title=A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis. |journal=Ann. Rheum. Dis. |volume=66 |issue= 3 |pages= 320–4 |year= 2007 |pmid= 17028114 |doi= 10.1136/ard.2006.058917External links
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