FCAR

Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human gene.cite web | title = Entrez Gene: FCAR Fc fragment of IgA, receptor for| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2204| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Ten transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: FCAR Fc fragment of IgA, receptor for| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2204| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Morton HC, van Egmond M, van de Winkel JG |title=Structure and function of human IgA Fc receptors (Fc alpha R). |journal=Crit. Rev. Immunol. |volume=16 |issue= 4 |pages= 423–40 |year= 1997 |pmid= 8954257 |doi=
*cite journal | author=Morton HC, Brandtzaeg P |title=CD89: the human myeloid IgA Fc receptor. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=49 |issue= 3 |pages= 217–29 |year= 2001 |pmid= 11478396 |doi=
*cite journal | author=Martin AM, Kulski JK, Witt C, "et al." |title=Leukocyte Ig-like receptor complex (LRC) in mice and men. |journal=Trends Immunol. |volume=23 |issue= 2 |pages= 81–8 |year= 2002 |pmid= 11929131 |doi=
*cite journal | author=Monteiro RC, Van De Winkel JG |title=IgA Fc receptors. |journal=Annu. Rev. Immunol. |volume=21 |issue= |pages= 177–204 |year= 2003 |pmid= 12524384 |doi= 10.1146/annurev.immunol.21.120601.141011
*cite journal | author=Kremer EJ, Kalatzis V, Baker E, "et al." |title=The gene for the human IgA Fc receptor maps to 19q13.4. |journal=Hum. Genet. |volume=89 |issue= 1 |pages= 107–8 |year= 1992 |pmid= 1577457 |doi=
*cite journal | author=Maliszewski CR, March CJ, Schoenborn MA, "et al." |title=Expression cloning of a human Fc receptor for IgA. |journal=J. Exp. Med. |volume=172 |issue= 6 |pages= 1665–72 |year= 1991 |pmid= 2258698 |doi=
*cite journal | author=Pfefferkorn LC, Yeaman GR |title=Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2. |journal=J. Immunol. |volume=153 |issue= 7 |pages= 3228–36 |year= 1994 |pmid= 7522255 |doi=
*cite journal | author=de Wit TP, Morton HC, Capel PJ, van de Winkel JG |title=Structure of the gene for the human myeloid IgA Fc receptor (CD89). |journal=J. Immunol. |volume=155 |issue= 3 |pages= 1203–9 |year= 1995 |pmid= 7636188 |doi=
*cite journal | author=Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M |title=HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro. |journal=J. Leukoc. Biol. |volume=55 |issue= 4 |pages= 545–51 |year= 1994 |pmid= 8145026 |doi=
*cite journal | author=Monteiro RC, Hostoffer RW, Cooper MD, "et al." |title=Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals. |journal=J. Clin. Invest. |volume=92 |issue= 4 |pages= 1681–5 |year= 1993 |pmid= 8408621 |doi=
*cite journal | author=Morton HC, van den Herik-Oudijk IE, Vossebeld P, "et al." |title=Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29781–7 |year= 1996 |pmid= 8530370 |doi=
*cite journal | author=Morton HC, Schiel AE, Janssen SW, van de Winkel JG |title=Alternatively spliced forms of the human myeloid Fc alpha receptor (CD89) in neutrophils. |journal=Immunogenetics |volume=43 |issue= 4 |pages= 246–7 |year= 1996 |pmid= 8575829 |doi=
*cite journal | author=Patry C, Sibille Y, Lehuen A, Monteiro RC |title=Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. |journal=J. Immunol. |volume=156 |issue= 11 |pages= 4442–8 |year= 1996 |pmid= 8666819 |doi=
*cite journal | author=Carayannopoulos L, Hexham JM, Capra JD |title=Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1. |journal=J. Exp. Med. |volume=183 |issue= 4 |pages= 1579–86 |year= 1996 |pmid= 8666916 |doi=
*cite journal | author=Pleass RJ, Andrews PD, Kerr MA, Woof JM |title=Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils. |journal=Biochem. J. |volume=318 ( Pt 3) |issue= |pages= 771–7 |year= 1996 |pmid= 8836118 |doi=
*cite journal | author=Reterink TJ, Verweij CL, van Es LA, Daha MR |title=Alternative splicing of IgA Fc receptor (CD89) transcripts. |journal=Gene |volume=175 |issue= 1-2 |pages= 279–80 |year= 1996 |pmid= 8917112 |doi=
*cite journal | author=van Dijk TB, Bracke M, Caldenhoven E, "et al." |title=Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils. |journal=Blood |volume=88 |issue= 11 |pages= 4229–38 |year= 1996 |pmid= 8943858 |doi=
*cite journal | author=Toyabe S, Kuwano Y, Takeda K, "et al." |title=IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. |journal=Clin. Exp. Immunol. |volume=110 |issue= 2 |pages= 226–32 |year= 1997 |pmid= 9367406 |doi=
*cite journal | author=Gulle H, Samstag A, Eibl MM, Wolf HM |title=Physical and functional association of Fc alpha R with protein tyrosine kinase Lyn. |journal=Blood |volume=91 |issue= 2 |pages= 383–91 |year= 1998 |pmid= 9427690 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes