- Superhelix
A superhelix is a molecular structure in which a
helix is itself coiled into a helix. This is significant to bothprotein s andgene tic material, such as overwound circularDNA .The earliest significant reference in
molecular biology is from1971 , by F.B. Fuller::"A geometric invariant of a
space curve , the writhing number, is defined and studied. For the central curve of a twisted cord the writhing number measures the extent to which coiling of the central curve has relieved local twisting of the cord. This study originated in response to questions that arise in the study of supercoiled double-stranded DNA rings." (See Reference 1).About the writhing number, mathematician W.F. Pohl says:
:"It is well-known that the writhing number is a standard measure of the global geometry of a closed space curve." (See Reference 2).
Contrary to intuition a topological property, the
linking number , arises from the geometric properties twist and writhe according to the following relationship::"L""k" = "T" + "W",
where "L""k" is the linking number, "W" is the
writhe and "T" is the twist of the coil.The linking number refers to the number of times that one strand wraps around the other. In DNA this property does not change and can only be modified by specialized enzymes called
topoisomerase s.ee also
*
Knot theory
*Supercoil References
#cite journal
author = Fuller, F. Brock
title = The writhing number of a space curve
journal =Proceedings of the National Academy of Sciences
volume = 68
year = 1971
pages = 815–819
id = MathSciNet | id = 0278197
doi = 10.1073/pnas.68.4.815
pmid = 5279522
#cite journal
author = Pohl, William F.
title = The self-linking number of a closed space curve
journal =Journal of Mathematics and Mechanics
volume = 17
year = 1968
pages = 975–985
id = MathSciNet | id = 0222777
doi = 10.1512/iumj.1968.17.17060
# [http://www.rpi.edu/~bellos/new_page_1.htm DNA Structure and Topology] . Molecular Biochemistry II: The Bello Lectures.External links
* [http://mathworld.wolfram.com/CalugareanuTheorem.html Calugareanu Theorem] - From
Wolfram Research 'sMathWorld .
* [http://mathworld.wolfram.com/Writhe.html Writhe] - From MathWorld.
* [http://mathworld.wolfram.com/Twist.html Twist] - From MathWorld.
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